Pharm: Tobacco, Vaping, Medical MJ, CBD Flashcards
Why are adolescents more vulnerable to using drugs/addiction?
incomplete prefrontal cortex development
How does nicotene affect adolescents?
interferes with the maturation (neuroplasticity is impaired) –>
- long term cognitive impairment
- decreased memory and attention
- behavior disturbances later in life
What vaping ingredient is theorized to be involved in lung damage?
vitamin E acetate
safe to ingest, not safe to inhale
What are the main cannabinoids?
THC
CBD
What is the MOA of MJ?
stimulates endocannabinoid receptors (CB1, CB2)
What is anadamide?
partial CB1R agonist
broken down by fatty acid amide hydrolysis (FAAH)
What is mediated by CB1Rs?
analgesia
appetite enhancement
muscle relaxation
hormonal actions
Dronabinol is a ___.
synetheic THC
used for: anorexia in AIDS pts, chemotherapy induced N/V, obstructive sleep apnea
*nabilone - THC capsule used for chemo induced N/V
What substance can improve spasticity in MS pts?
cannabis
What conditions does cannabis lack efficacy?
acute pain
HD
tremor in MS
glaucoma
schizophrenia
depression
slowing cancer growth
CIs of Cannabis
hx of psychosis
current or past substance abuse disorder
CV or respiratory disease
What would be the theoretical benefit of a FAAH inhibitor?
less breakdown of endocannabinoids anandamide –> less pain, axiety, fear…
How CBD is generally adminstered?
orally
metabolized via CYP3A4 and CYP2C19
rapidly distrubutes, and accumulates in adipose tissue
At what receptors is CBD an agonist?
CB1
CB2
TRPV1
PPARy
5-HT1A
What are the benefits of CBD tx?
no CV effects
no psychoactive effects
no potential for abuse
no tolerance/withdrawal
no effect on embryo development
