pharma

Question 1

treatment of EPS?

Answer 1

anticholinergic meds (benztropine), benzos, BB

EPS caused by antidopaminergic

Question 2

b1 selective blockers

Answer 2

BEAM

Question 3

amicar MOA

Answer 3

lysine analog that competitively binds to plasminogen

Question 4

MOA of TPA

Answer 4

binds to fibrin and fibrinogen. also increases conversion of plasminogen to plasmin

Question 5

hetastarches and coagulopathy

Answer 5

decrease glycoprotein II/III availability

decreases vwf and factor 8

Question 6

how is nicardipine metabolized?

Answer 6

liver

coronary AND peripheral arterial dilator

does NOT decrease cardiac function - actually can cause tachycardia in 25% not due to baroreceptor but rather to sympathetic stimulation

Question 7

stats tests and when to use them

Answer 7

Chi-square: categorical
t-test: ratio (interval but with meaningful 0)
whilcox-manning-whitney: ordinal (order that doesnt mean objectively)

Question 8

what meds induce P450 (necessitating increased doses of meds?)

Answer 8

barbiturates, rifampin, etoh, phenytoin, carbamazepine

Question 9

what meds inhibit p450 (necessitating DECREASED doses?)

Answer 9

valproic acid, fluconazole, metronidazole, ciprofloxacin

Question 10

how does codeine get to active form?

Answer 10

CYP2d6 (active form is morphine)

fluoxetine inhibits cyp2d6 so LESS effective

Question 11

formula to estimating bicarb

Answer 11

0.2 * body weight in kg * base deficit

Question 12

normal airway compliance in healthy, mechanically ventilated patient

Answer 12

50-100

Question 13

the MOST important predictor of hypoxemic during OLV

Answer 13

PaO2 <80-90 prior to initiation of OLV