Pharma

Question 1

strongest acid/alkali
is always found
In

Answer 1

ionised form

Eg: heparin

Question 2

Forced alkalisation done using

Answer 2

Na bicarb

Aceto zolami de

Question 3

urine acidification done by

Answer 3

ascorbic acid Ammonium Chloride

Question 4

Absorption -…… form

excretion …… form

Answer 4

nonionised

Ionised

Question 5

Henderson hesselback equation

Answer 5

pka= ps+ log (Ionised A / unionised A )

Question 6

PKA =pH H H equation

Answer 6

50%

Question 7

P.glycoprotein inhibitors

Answer 7

VAQCINE
Nera pamil
amiodarone Cyclosporine Itraconazole Nifedipine erythromycin Quinidine

Question 8

Most potent p glyco

inhibitor

Answer 8

Verapamil

Question 9

Eg: ofa drug affected ey p-glycoprotein

Answer 9

digoxin

BA dec

Question 10

P. glycoprotein induces

Answer 10

Rifampicin St. John’s wort
Phenytoin
carbamazepine

Question 11

Bioequivalent drugs

Answer 11

BA diff <20%.

Question 12

Rear for passive transport

Answer 12

lipid soluble

Non ionised

Question 13

uptake of AA by brain

is a form of

Answer 13

facilitated

diffusion

Question 14

heast canon method
of drug transport
with eg

Answer 14

Pinocytosis

insulin

Question 15

any 4 orphan

drugs

Answer 15

Fomi pizole
Leothysonine
Digi band
Protamine sulfate

Question 16

active form of

thyroxine? used in?

Answer 16

mynedema coma

Question 17

essential drugs must be

Answer 17

affordable
available
single compound

Question 18

Dang distr i b ution in

3 components

Answer 18

42=4+10+28

Question 19

chloroquine digoxin TCA low/high vd

Answer 19

Large Vd

Question 20

Avoid dialy sis in poison oning

of what kind of drugs

Answer 20

Large Vd
AVOID Dialysis
Amphetamine Verapamil OPC opioids Imipramine (TCA) D igoxin Diazepam

Question 21

Eg: of adrug swith strong plasma

protein binding

Answer 21

Diazepam

Question 22

Vd formula

Answer 22

total dose / Plasma concentration

Question 23

Loading dose =

Answer 23

Vd x target plasma

concentration

Question 24

T1/2=

Answer 24

0:693 x Vd /clearance

Question 25

Clearance =

Answer 25

rate of elimination /plasma concentration

Question 26

Maintenance dose | =

Answer 26

cLx plasma conc

Question 27

Acidic drugs usually bind basic.

Answer 27

Albumin | x-1 acid glycoprotein

Question 28

aI acid glycoprotein increased in

Answer 28

MI, | Burns Trauma

Question 29

Aspirin displaces ...... from protein | binding site

Answer 29

Tolbutamide | Warfarin

Question 30

...... displaces | bilirubin i n

Answer 30

sulphonamide c(I newborn keen icterus

Question 31

G1 phase enzyme

Answer 31

L- asparaginese

Question 32

CDK4,6 inhibitors

Answer 32

Palbo ciclib Abema ciclib Ribociclib

Question 33

ADR an uses of | L- asparaginese

Answer 33

hemorrhagic pancreatitis hypecoagulation ALL E. coli

Question 34

Steroids

Question 35

steroids act on | which phase

Answer 35

S

Question 36

Tenoposide | Stop oside

Answer 36

Epipodophyllotoxin

Question 37

Tenoposide | Stop oside

Answer 37

Epipodophyllotoxin

Question 38

Topoi somerase I | inhibitor

Answer 38

Irinotecan Topote can G2

Question 39

Topoisomerase II inhibifor

Answer 39

Etoposide Tenoposide Antheacycline antibiotics

Question 40

Dose limiting ttoxicity of Irinote can

Answer 40

Diarrhea

Question 41

drugs acting on M | phase

Answer 41

Vinca alkaloids Taxanes Ixabepilone Erbul in

Question 42

Estramustim

Answer 42

M. phase | Prostate cancer

Question 43

all anti biotic anticancer drugs are cytotoxic except

Answer 43

Bleomycin

Question 44

Permetrexed Trimetrered

Answer 44

Mesothelioma Non small cell lung cancer anti folate

Question 45

Pralatrexate | Ralti thaxate

Answer 45

1- cutaneous T- cell lymphoma 2. Mesothelioma colOrectal ca

Question 46

antidote for anti folate | exept M+x

Answer 46

Vit B12+ Folic acid

Question 47

MOA MTX

Answer 47

MTX PG inbulents DH FR

Question 48

_ ... increase M tx action

Answer 48

P. glycoprotein inhibitors

Question 49

DOC for choriocarcinoma

Answer 49

Mtx

Question 50

Mfx as DMARD dose

Answer 50

7.5 mg) week

Question 51

loco close long term Mtx used in

Answer 51

R.A.

Question 52

ADR MTX

Answer 52

``` my elo suppression Alopecia GI toxicity long term - hepato toxiatry crystall ria ```

Question 53

Folinic Acid raikk overncome | all ADR of Mtx except

Answer 53

Neurotoxinty?

Question 54

- ...... lused as antidote fOr pts with Mtx toxicity and kidney disease

Answer 54

GLUCAR BIDASE

Question 55

Purine antimet abolites

Answer 55

``` 6_Thio guanine 6-Mencaptopurine Fludarabine C ladribine Pento statin ```

Question 56

DOC_hairy call leukemia

Answer 56

Gladri bine

Question 57

Pentostatin

Answer 57

adenosine deaminase inhibitors CLL

Question 58

active form of 6-MP

Answer 58

6- Thiosinic acid

Question 59

Leesh Nyhan synchome

Answer 59

def of HGPRT

Question 60

xanthine oxidase inhibitors

Answer 60

allopurinol | febunostat

Question 61

Pyramidine anti metabolites

Answer 61

Cytarabine 5-FU Gemcitab ine Capecitabine

Question 62

ADR cytarabine

Answer 62

Myelosuppression Cerebellar ataxia dysarthria

Question 63

leucomisole

Answer 63

``` anti helmin this agent having immunostimulatory action colorectal ca (along with 5-FU) ```

Question 64

5 Fu lencoverin interaction

Answer 64

L increases action of 5 FU

Question 65

Topical use of sFU

Answer 65

BCC keratosis

Question 66

hand foot synchome

Answer 66

vasospasmic action | of 5-FU

Question 67

DOC adenocarcinoma pancreas

Answer 67

G emcitab ine

Question 68

Radio sensitizer

Answer 68

Gemci +abine

Question 69

maximum risk of | hand foot syndrome

Answer 69

capecitabine | pro drUg S-FU

Question 70

Radiation recall reaction | seen in

Answer 70

Actinomycin D max | Dannorubicin Doxorubicin Mizoxandrone

Question 71

Cardio tomic anticancer antibiotics

Answer 71

Danno rubicin Doxo rubicin Mitoxantrone

Question 72

Mitoxantrone | used in

Answer 72

multi ple sclerosis

Question 73

uses of adriamycin

Answer 73

``` ALL AML Breast ca Osteosarco ma MHL HL ```

Question 74

antidote doxorubicin

Answer 74

Dexrazoxane | + Alpha tocopherol