Pharma-anti HIV drugs

Question 1

Drug group that Competitively inhibits BINDING OF NATURAL nucleotides to rev transcriptase
Also acts as chain terminators

Answer 1

NRTI

Question 2

T/F

NRTI lacks 5’- hydroxyl group

Answer 2

F.

3’

Question 3

Resistance to NRTI due to

Answer 3

pol GENE MUTATION

Question 4

Pancreatitis toxicity is dose limiting for this NRTI

Answer 4

Didanosine

Question 5

Once daily dosing,

CI in preggies and young children due to propylene glycol content

Answer 5

Emtricitabine

Question 6

anti HIV that is also effective vs HEPa B

Answer 6

Lamivudine

Question 7

Lamivudine excreted almost exclusively by …

Answer 7

Kidney

Question 8

NRTI with good tissue penetration with oral dosing, incl CNS

Answer 8

Stavudine

Question 9

AE more frequently observed in Stavudine

Answer 9

Lactic acidosis with hepatic steatosis

Question 10

a nucleotide NRTI also with HEpa B activity

Answer 10

Tenofovir

Question 11

Tenofovir impede renal elimination of

Answer 11

Acyclovir

Ganciclovir

Question 12

NRTi with periph neuropathy as dose limiting factor

Dr zialCITA, Nuero Proph~` ~ periph neuropatihy

Answer 12

zalCITAbine

Question 13

This drug increases clearance of ZIDOVUDINE

Answer 13

Rifampin

Question 14

This group of drug does not require phosphorylation to be activated
binds to site in Rev transc diff from NRTI

resistance due to

Answer 14

NNRTI

Pol gene mutation

Question 15

Major problem is drug interaction,

CYP2D6, CYP3A4

Answer 15

Delavirdine

Question 16

Once daily dosing NNRTI

toxicity include elevated serum cholesterol level
CI in 1st tri pregnancy

Answer 16

Efavirenz

Question 17

For HIV resistant to other drug groups

Answer 17

Etravirine

Question 18

Effective in preventing VIRtical transmission

given to mother once at labor and to neonate

Answer 18

neVIRapine

Question 19

Nevirapine levels inc by

Answer 19

Cimetidine, Macrolides

Question 20

Nevirapine levels dec by

Answer 20

Enzyme inducers

Question 21

Dependent on ASPartate Protease (HIV-1 portease)

Answer 21

Protease inhibitors.

-navirs

Question 22

PI given OD
Requires ACIDIC environment
Penetrates:: CSF, seminal fluid
biliary elimination

Answer 22

Atazanavir

Question 23

T/F

Atazanavir associated with Dyslipidemia, fat deposition, metabolic syndrome

Answer 23

False.

Unlike most PIs

Question 24

PI with propylene glycol, not for preggies or children

Answer 24

Fosamprenavir

Question 25

PI with inc INsuline resistnace

Answer 25

Indinavir

Question 26

PI with increased oral absorption with food intake

Answer 26

Nelfinavir

Question 27

Combination with this PI allows for lowering dose of the partner PI

Answer 27

Ritonavir subtherapeutic levels inhibits CYP3A4 mediated metab of other PI

Question 28

PI that increase blood level of HMG Coa Reductase inhibitors by inducin p glycoprotein transporters

Answer 28

Tipranivir inc risk for Rhabdo and Myopathy

Question 29

IN HIV attachment HIV ____ attaches to CD4 ____

Answer 29

gp120 to CCR5

Question 30

Target of maraviroc

Answer 30

ccr5

Question 31

Target of ENfuvirtide

Answer 31

gp41 prevents viral fusion with cell membrainne

Question 32

Resistance to ENfurVirtide

Answer 32

ENV gene mutation

Question 33

Binds integrase

Answer 33

Raltegravir for tx naiive HIV patients

Question 34

Raltegravir dose should be ____ when used with Rifampin

Answer 34

Doubled