pharma pt 2

Question 1

indications adrenaline

Answer 1

anaphylaxis + cardiac arrest

Question 2

dose adrenaline anaphylaxis and cardiac arrest

Answer 2

anaphlyaxis = 500mcg // cardiac arrest = 1g

Question 3

effects of adrenaline

Answer 3

vasoconstriction in skin –> narrow pulse // vasodilation in skeletal muscles // inhibits insulin

Question 4

mechanism flecainide

Answer 4

slows AP by blocking Na channel –> wide QRS + prolonged PR

Question 5

indications flecainide

Answer 5

AF // SVT eg WPW

Question 6

contraindications flecainide

Answer 6

post MI, HF, AV block, flutter

Question 7

SE flecainide

Answer 7

negatively inotropic (weaken heart) // bradycardia // arrhythmia // oral paraesthesia // vision

Question 8

mechanism digoxin

Answer 8

decreased AV node conduction // inhibits NaKATPase (increases force of heart)

Question 9

monitoring digoxin

Answer 9

only in toxicity // measure within 8-12hrs last dose

Question 10

levels indication digoxin toxicity

Answer 10

1.5-3

Question 10

features digoxin toxicity

Answer 10

anorexia, confused, yellow-green vision // arrhythmia // gynaecomastia

Question 11

RF digoxin toxicity

Answer 11

hypokalamia // renal failure // MI // hypo- // drugs

Question 12

what meds increase risk of digoxin toxicity

Answer 12

amiodarone, verapamil, diltiazem, ciclosporin // hypokalaemmic drugs eg thiazides, loops

Question 13

mx digoxin toxicity

Answer 13

digibind, correct arrhythmia, monitor K

Question 14

examples alpha blockers

Answer 14

doxazosin + tamsulosin

Question 15

SE alpha blocker

Answer 15

postural hypotension // drowsy // SOB // cough

Question 16

examples K sparing diuretics

Answer 16

amiloride + spironolactone

Question 17

when do K sparing diuretics have to be given with caution

Answer 17

ACEi –> hyperK

Question 18

indications spironolactone

Answer 18

ascites // HF // Conns // nephrotic syndrome // resistant HTN

Question 19

features BB overdose

Answer 19

bradycardia, hypotension, HF, syncope

Question 20

mx BB overdose

Answer 20

atropine // glucagon

Question 21

contraindications diclofenax

Answer 21

IHD, PAD, cerebrovascular disease, congestive HG

Question 22

monitoring statin

Answer 22

LFT at baseline, 3 month, 12 months