Pharmacodynamics

Question 1

Relative contraindication

Answer 1

Caution should be used. Benefits must outweigh the risk

Question 2

Absolute contraindication

Answer 2

Event or substance could cause life threatening situation. Do not do!

Question 3

Prototype drug

Answer 3

Lead agent in a drug class (family)

Question 4

Pharmacologic classification

Answer 4

Based on what medication does to body or grouped by outcomes

Question 5

Mechanism of action

Answer 5

How medication works in the body

Question 6

Therapeutic indication

Answer 6

That the medication is indicated to treat

Question 7

Major adverse reactions

Answer 7

Any major side effects that have been reported

Question 8

Clinically significant Drug

Answer 8

Drugs that interact with that medication

Question 9

Contraindication

Answer 9

Serious side effects to consider when prescribing to patients

Question 10

Receptor

Answer 10

Biologic molecule that binds a drug (ligand) to produce measurable response

Question 11

Antagonist

Answer 11

Block endogenous/ natural agonists. No intracellular effects. Compete for binding site or allosteric changes to prevent binding

Question 12

Angonist

Answer 12

Drugs that bind to trigger secondary messages or intracellular messaging.

Question 13

Ion channels

Answer 13

Drug receptor site- Rapid response, regulate flow of ions across membrane

Question 14

Pumps

Answer 14

Inhibition of ongoing basal activity to targets i.e. proton pumps

Question 15

Enzymes

Answer 15

Transmembrane receptors, activate an intracellular enzyme. Increase rate of reaction

Question 16

Chemical name

Answer 16

How drug is built and works in the body based on chemical structure. Structure defines affinity for receptor binding and secondary messaging

Question 17

Generic name

Answer 17

designation for active ingredient. Publicly held name determined by us council.

Question 18

Trade

Answer 18

Given by pharmaceutical company

Question 19

Chemical Structure

Answer 19

Determines receptor affinity and cascade. Not a helpful designation for PAs

Question 20

pharmacologic action

Answer 20

mechanisms of action, biochemical interaction and pharm effect

Question 21

therapeutic class

Answer 21

purpose of treatment (anti-inflammatory, anti- bacterials)

Question 22

Schedule 1

Answer 22

Illegal, no medical use. High potential for abuse

Question 23

Schedule II

Answer 23

High potential for abuse, high risk dependance, accepted medical use. Can’t be refiled, order must be written

Question 24

Schedule III

Answer 24

Possible potential for abuse, accepted medical use. May be refilled 5x in 6 months- anabolic steroids

Question 25

Schedule IV

Answer 25

Low potential for abuse, accepted medical use, may lead to dependance Refill 5x in 6 months- Ambian and benzos

Question 26

Schedule V

Answer 26

Low potential for abuse, limited risk of dependance- robitussin

Question 27

Bioequivaence

Answer 27

Two drug preparations show comparable bioavailablity and similar times to achieve peak blood concentrations

Question 28

Theraputic equivalence

Answer 28

Bioequivalent and pharmaceutically equivalent- same clinical effect and safety profile when administered.