Flashcards in Pharmacodynamics Deck (13):
What the body does to the drug..study of absorption, distribution, metabolism, and excretion of drugs.
What the drug does to the body...study of the biological and therapeutic effect of drugs
Drug that increases the strength of contraction of cardiac muscle
Drugs that decrease heart rate
What does MOA stand for and what is it?
Mechanism of action: how the drug works aka which proteins are affected.
What does EC50 mean?
A drugs effective concentration at 50% of the max effect.
What does IC90 mean?
The drugs inhibitory concentration at 90% inhibition.
What is an orthosteric site?
A site where native ligand of drug bind to a target
What is an allosteric site?
A different site other than the primary (orthosteric) site where the native ligand binds to a target.
What types of bonds are used to link drugs and protein targets?
Covalent and non-covalent bonds
If a drug is a reversible binder, what type of bond will be involved with it and the protein target?
Non- covalent like hydrogen bonds and van der wallas interactions (these aren't strong bonds)
If a drug is an irreversible binder, what type of bond will be involved?