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Flashcards in Pharmacodynamics Deck (13):
1

Pharmacokinetics (PK)

What the body does to the drug..study of absorption, distribution, metabolism, and excretion of drugs.

2

Pharmacodynamics (PD)

What the drug does to the body...study of the biological and therapeutic effect of drugs

3

Positive inotrope

Drug that increases the strength of contraction of cardiac muscle

4

Negative chronotrope

Drugs that decrease heart rate

5

What does MOA stand for and what is it?

Mechanism of action: how the drug works aka which proteins are affected.

6

What does EC50 mean?

A drugs effective concentration at 50% of the max effect.

7

What does IC90 mean?

The drugs inhibitory concentration at 90% inhibition.

8

What is an orthosteric site?

A site where native ligand of drug bind to a target

9

What is an allosteric site?

A different site other than the primary (orthosteric) site where the native ligand binds to a target.

10

What types of bonds are used to link drugs and protein targets?

Covalent and non-covalent bonds

11

If a drug is a reversible binder, what type of bond will be involved with it and the protein target?

Non- covalent like hydrogen bonds and van der wallas interactions (these aren't strong bonds)

12

If a drug is an irreversible binder, what type of bond will be involved?

Covalent

13

Why are time-dependent inhibition drugs avoided?

Their levels increase in the plasm