Pharmacogenomics Flashcards
(19 cards)
What three medications are effected by the gene CYP2D6?
Tamoxifen
Codeine
Paroxetine
What two medications are effected by CYP2C19?
Clopidogrel
Omeprazole
What genes effect Warfarin use?
CYP2C9 and VKOR.
What medication is effected by the gene SLCO1B1?
Simvastatin
What medication is effected by the genes DPD and TYMS?
F-flurouracil (5FU)
What medication is effected by the gene TPMT?
6-mercaptopurine (6-MP)
What medication is affected by the gene ERalpha?
Estrogen/Progesterone
What medication is affected by ADRB2?
Albuterol
What medication is affected by the gene HLA-B?
Abacavir
What medication is affected by the gene IL28B?
Interferon alpha
Of all the medications we have studied, which cause pharmacodynamic phenotypes?
Genes ERalpha and ADRB2 both cause pharmacodynamic issues.
ERalpha - Estrogen/progesterone
ADRB2 - Albuterol
When comparing mutations to polymorphisms which appears in more than 1% of the population?
Polymorphisms are the difference in DNA code that occurs in more than 1% of the population.
Within the population there can be many alleles of a particular gene.
What are cosmopolitan polymorphisms?
Polymorphisms common across all ethic groups.
What are population polymorphisms?
These are polymorphisms that differ between groups (ethnic or race)
What is a candidate gene approach?
Determine polymorphisms by genotyping a predicted specific gene.
Might accidentally study teh wrong gene.
What is Genome wide approach to phenotype to genotyping?
Unbiased survey of all difference in entire genome between two groups.
Con is that the identification of genetic differences do not tell you how it effects the drugs response.
Whats the difference between pharmacodynamic phenotypes and pharmacokinetic?
Pharmacodynamic effects the way a drug targets receptors/enzymes etc.
Pharmokinetic is going to be the way the drug is metabolized or transported or what concentrations there are.
What correlation does CYP2D6 have to tamoxifen levels?
High metabolizers will have greatly increased tamoxifen levels.
What correlation does CYP2D6 have with codeine?
Increase conversion of codeine to morphine.
