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Flashcards in Pharmacokinetic Equations Deck (15)
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1

Amount of Drug Absorbed

= (S)(F)(Dose)

2

Dose of Different Dosage Form

= [Amount(mg) absorbed current form] / [(S)(F) of new dosage form]

3

Concentration in plasma (Cp)

= [(S)(F)(Dose)] / (Vd)

4

Loading Dose

= [(Vd)(Cp)] / [(S)(F)

5

Supplemental Loading Dose

= [(Vd)(Cp desired - Cp initial)] / [(S)(F)]

6

Clearance (Cl)

= (S)(F)(Dose/tau) / (Cp ss avg)

7

Tau

frequency in hours

8

Maintenance Dose

= [(Cl)(CPss avg)(tau)] / [(S)(F)]

9

Elimination rate constant (K el)

= (Cl)/(Vd)

10

Half-life (t1/2)

= 0.693/(K el)

11

K el

Elimination rate constant

12

Vd

volume of distribution

13

S

salt factor (1)

14

F

bioavailability factor (1)

15

Cp

concentration in plasma