Pharmacokinetic Equations Flashcards
(15 cards)
1
Q
Amount of Drug Absorbed
A
= (S)(F)(Dose)
2
Q
Dose of Different Dosage Form
A
= [Amount(mg) absorbed current form] / [(S)(F) of new dosage form]
3
Q
Concentration in plasma (Cp)
A
= [(S)(F)(Dose)] / (Vd)
4
Q
Loading Dose
A
= [(Vd)(Cp)] / [(S)(F)
5
Q
Supplemental Loading Dose
A
= [(Vd)(Cp desired - Cp initial)] / [(S)(F)]
6
Q
Clearance (Cl)
A
= (S)(F)(Dose/tau) / (Cp ss avg)
7
Q
Tau
A
frequency in hours
8
Q
Maintenance Dose
A
= [(Cl)(CPss avg)(tau)] / [(S)(F)]
9
Q
Elimination rate constant (K el)
A
= (Cl)/(Vd)
10
Q
Half-life (t1/2)
A
= 0.693/(K el)
11
Q
K el
A
Elimination rate constant
12
Q
Vd
A
volume of distribution
13
Q
S
A
salt factor (1)
14
Q
F
A
bioavailability factor (1)
15
Q
Cp
A
concentration in plasma
