PHARMACOKINETICS

Question 1

It is the release of active ingredient from its dosage from

Answer 1

Liberation

Question 2

Rate-limiting step in Liberation

Answer 2

Dissolution

Question 3

(T/F) Free form drugs dissolve much readily than Salt forms

Answer 3

False (Salt form dissolves more readily)

Question 4

The only drug form that goes through liberation

Answer 4

Solid Dosage forms

Question 5

Disintegration is when __________ and Dissolution is when ________

Answer 5

Solid dosage form breaks apart
Solid dosage form is dissolved in a solvent

Question 6

Its main objective is turn a drug into an aqueous solution

Answer 6

Liberation

Question 7

(T/F) Hydrated form is much readily soluble than anhydrous form

Answer 7

False (Anhydrous form is much readily soluble)

Question 8

(T/F) Amorphous drug forms are much readily soluble than crystalline form

Answer 8

True

Question 9

It is the rate and extent of drug entry into the systemic circulation

Answer 9

Absorption

Question 10

Refers to the proportion of drug that is delivered to site of action

Answer 10

Bioavailability

Question 11

(T/F) The greater the dose, the greater the absorption

Answer 11

True

Question 12

Higher blood supply, faster absorption

Answer 12

Degree of perfusion

Question 13

It has the highest absorbing surface

Answer 13

Gastro-Intestinal Tract (120 - 200 sq. m)

Question 14

The large surface area of the gastro-intestinal tract is due to the presence of _____________

Answer 14

Macrovilli
Microvilli

Question 15

Weak Acidic drugs are more readily absorbable in the ________

Answer 15

Stomach

Question 16

The stomach does not have good absorption capabilities due to it having _________

Answer 16

A thick mucus layer

Question 17

It refers to the time it takes for the stomach to empty its contents

Answer 17

Gastric Emptying Rate (GER)

Question 18

Part of the small intestine that has the greatest capacity to absorb drugs

Answer 18

Duodenum

Question 19

(T/F) Gastric Emptying Time is inversely related to Gastric Emptying Rate

Answer 19

True

Question 20

(T/F) Small and Large uncharged particles can pass through the cell membrane

Answer 20

False (Only small uncharged particles can enter)

Question 21

The cell membrane is made out of?

Answer 21

Phospholipids

Question 22

(T/F) Ketoconazole (anti-fungal) can be taken with antacids

Answer 22

False (Ketoconazole is best in an acidic environment)

Question 23

Refers to when drugs that are partially metabolized in the liver or portal vein before passing into the circulatory system

Answer 23

First-pass effect

Question 24

Route of administration that has the most rapid onset

Answer 24

Intravenous (IV)

Question 25

Examples of Drugs with extensive FPE

Answer 25

Morphine Propranolol Catecholamines