Pharmacokinetics Flashcards
(7 cards)
1
Q
What does ADME stand for?
A
- Absorption
- Distribution
- Metabolism
- Excretion
2
Q
What is the term “ADME” interchangeable with?
A
Pharmacokinetics
3
Q
What does drug absorption refer to?
A
Dose of drug administered and absorbed
4
Q
What is pharmacokinetics? (2)
A
- Interpreting data on changing drug and metabolites concs/amounts in body tissues/fluids
- What the body does to the drug
5
Q
Why is ADME important? (4)
A
- To know if drug absorbed if given by particular route
- To estimate accurate plasma conc of drug as fraction of time
- To know where drug goes in body
- To know if drug metabolites are safe
6
Q
Why is it important to estimate accurate drug plasma concentrations as a fraction of time?
A
Drug plasma concentration is dynamic - changes with time
7
Q
Give an example of a drug where drug distribution knowledge prevented side effects (5)
A
- Piriton = hayfever drug with drowsiness side effect
- Blocked histamine receptors in nasal passages and eyes (anti hayfever)
- But also blocked histamine receptors in brain = drowsiness
- Claritin = hayfever drug without drowsiness side effct
- Structure altered so can’t cross blood brain barrier but still blocks periphery histamine receptors
