Pharmacology Flashcards
(14 cards)
What is used in the reversal of anaesthetic?
?
What are the side effects of sodium valproate?
Weight gain Nausea Alopecia Ataxia, tremor, Hepatitis, pancreatitis Thrombocytopenia Tertatogenic Hyponatraemia
What is the first line management for migraine?
Oral Tristan and an nsaid
Can give metoclopramide (has anti-emetic benefit)
Which anti-emetic is known for the extra-pyramidal side-effects?
Metoclopramide
Particularly in children and young adults
Caution - acute dystonic reactions
Why is the COPC contraindicated in migraine with aura?
Increases risk of ischemic stroke
What Are the risk factors for subarachnoid haemorrhage?
Berry aneurysms - polycystic kidneys, ehlers-danlos, coarctation of the aorta,
Av malformations
Trauma
Tumours
What are you looking for in the LP 12 hours after subarachnoid haemorrhage?
Xanthochromia
What is the treatment for huntingtons disease?
Baclofen (gaba b aganosist)
S/e decrease appetite and sex, postural hypotension
Tetrabenazine (inhibits MOnoamine transport)(for hyperkinesis)
S/e Bradykinesia
Depression
Sedation
Why is procycline/ anti-cholinergics used in Parkinson’s?
Less dopamine = cholinergic hyperactivity lead to tremor
Therefore beneficial in treatment
How does sumatriptan work?
5-HT 1b/1d agonist,
Causes vasoconstrictor of cranial blood vessels therefore less neuropeptide release.
Used in migraine and cluster headache
What drugs are used in Alzheimer’s disease?
Memantine (NMDA anatagonist) this reduces glutamate excitotoxicity.
acetylcholinesterase inhibitors
Donepezil
Rivastigmine (patch)
Galantamine
Which drug reverses neuromuscular junction blockade?
Neostigmine
Has a use in MG treatment and at the end of operations.
What drug is used with L-DOPA as a peripheral inhibitor?
Benserazide
Or carbidopa
Which drug is used in the diagnosis of MG?
Edrophonium (tensilon test)
