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Case 5 > Pharmacology > Flashcards

Pharmacology Flashcards

1
Q

What is the MOA of salbutamol and salmeterol?

A

Selective B2 adrenoreceptor agonist = cAMP mediated bronchial SM relaxation

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2
Q

What are the ADR’s of salbutamol and salmeterol?

A

Angioedema, cardiac arrhythmias, hand tremors, urticaria, hypokalaemia

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3
Q

What are the CI’s of salbutamol and salmeterol?

A

CVD, arrhythmic, hypokalaemic

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4
Q

What is the MOA of fluticasone?

A

Steriod complex with glucocorticoid receptor = transcriptional regulator to strongly reduce inflam.

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5
Q

What are the ADR’s of fluticasone?

A

LT immune suppression, cushings, osteoporosis

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6
Q

What are the CI’s of fluticasone?

A

Immune compromised, diabetic

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7
Q

What is the MOA of Ipratropium + Tiotropium?

A

M3 ACh receptor antagonists = reduced cGMP = SM relaxation

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8
Q

What are the ADR’s of Ipratropium + Tiotropium?

A

Constipation, cough, diarrhoea, dry mouth, GI disturbances, headaches

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9
Q

What are the CI’s of Ipratropium + Tiotropium?

A

Arrhythmias, cardiac failure or MI past 6 months

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Case 5 (9 decks)

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