Respiratory Failure Flashcards

1
Q

What is hypoxaemia?

A

Lack of O2 in arterial blood

PaO2 < 8 kPa

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2
Q

What is hypercarbia?

A

Too much CO2 in arterial blood

PaCO2 > 7 kPa

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3
Q

What is type 1 respiratory failure?

A
  • Oxygenation failure
  • Hypoxaemia with normal/low PaCO2
  • Affects part of lung - remaining able to excrete CO2
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4
Q

What is type 2 respiratory failure?

A
  • Ventilatory failure
  • Hypoxaemia + Hypercarbia
  • Affects whole lung - inadequate ventilation = CO2 accumulation
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5
Q

What are the causes of type 2 RF?

A
  • Depression of respiratory centre
  • Respiratory muscle weakness
  • Chest wall deformity
  • Severe lung disease
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6
Q

What are the signs of low O2?

A

Confusion, restlessness, cyanosis, tachypnoea (rapid breathing)

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7
Q

What are the signs of high CO2?

A

Drowsiness, confusion, headache, agitation, bounding pulse, asterixis

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8
Q

How is type 2 RF treated?

A
  • Oxygen - LT 16 hours/day

- Poor prognosis

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9
Q

How is type 1 RF treated?

A
  • Ventilation + non-invasive ventilation
  • Even poorer prognosis
  • Overnight ventilation
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10
Q

What is normal blood pH?

A

7.35-7.45

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11
Q

What pH is alkalaemia?

A

pH > 7.45

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12
Q

What pH is acidaemia?

A

pH < 7.35

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13
Q

How are changes in CO2 controlled?

A

Changes in ventilation

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14
Q

How are changes in HCO3 controlled?

A

Renal absorption/excretion

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15
Q

What is normal oxygen saturation?

A

> 94 %

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16
Q

What causes respiratory acidosis/alkalosis?

A

Abnormal CO2 clearance

17
Q

What causes metabolic acidosis/alkalosis?

A

Abnormal regulation bicarbonate

18
Q

What is base excess?

A

Amount of acid required to return pH to normal at normal PaCO2

19
Q

What does a BE < -2 indicate?

A

Metabolic acidosis

20
Q

What does BE > + 2 indicate?

A

Metabolic alkalosis

21
Q

What does low pH, BE & HCO3 indicate?

A

Metabolic acidosis

Increased ventilation to blow off CO2

22
Q

What does high pH, BE & HCO3 indicate?

A

Metabolic alkalosis

Decreased ventilation to retain CO2

23
Q

What does low pH and high PaCO2 indicate?

A

Respiratory acidosis
Acute type 2 RF
Compensated metabolic alkalosis - excrete H+, retain HCO3

24
Q

What does high pH and low PaCO2 indicate?

A

Respiratory alkalosis
Hyperventilation
Acute + unstable to sustain for long
Compensated metabolic acidosis - kidneys excrete HCO3