Pharmacology - general Flashcards
(428 cards)
List adrenergic receptors
λ1, λ2, β1, β2, β3
λ1 receptors functions
–> in skin, sphincter of GI, kidneys, brain
–> contraction of smooth m of blood vessel
–> anorexia
–> mydriasis
–> + inotropic effect
λ2 receptors functions
–> in CNS, vascular smooth m.
–> inhibit release of noradrenaline
–> platelet aggregation
–> reduce salivation
β1 receptors functions
–> increase cardiac output
–> + chronotropic effect
–> + inotropic effect
–> renin release
–> lipolysis in adipose tissue
β2 receptors functions
–> resp, uterine, GI smooth m. relaxation
–> Increase blood flow in target organs
–> increase aqueous humor secretion
–> glycogenolysis and gluconeogenesis in liver
β3 receptors functions
–> gall bladder, urinary, fat
–> lipolysis in adipose tissue
–> thermogenesis in skeletal m.
Ephedrine
–> Sympathomimetic, non-catecholamine
–> hypertension
–> mydriasis
–> vasoconstriction (kidneys, mesenteric, skin)
–> For urinary incontinence
–> Decongestant
Amphetamine
–> Sympathomimetic, non-catecholamine
–> release noradrenaline
Phenylephrine
–> Sympathomimetic, non-catecholamine
–> peripheral vasoconstriction
–> Decongestant
Metoxamin
Metaramiol
–> Sympathomimetic, non-catecholamine
–> peripheral vasoconstriction
Ergometrine
–> Non selective λ adrenergic blocking agent
–> decrease vasoconstriction
–> treat perivascular spasm
–> anti-hypertensive
–> use in visceral ischemia
–> relaxation of 3rd eyelid
Phenoxibenzamine
–> Non selective λ adrenergic blocking agent
–> decrease vasoconstriction
–> treat perivascular spasm
–> anti-hypertensive
–> use in visceral ischemia
–> relaxation of 3rd eyelid
Dibenamine
–> Non selective λ adrenergic blocking agent
–> decrease vasoconstriction
–> treat perivascular spasm
–> anti-hypertensive
–> use in visceral ischemia
–> relaxation of 3rd eyelid
Phentolamine
–> Non selective λ adrenergic blocking agent
–> decrease vasoconstriction
–> treat perivascular spasm
–> anti-hypertensive
–> use in visceral ischemia
–> relaxation of 3rd eyelid
Talazoline
–> Non selective λ adrenergic blocking agent
–> decrease vasoconstriction
–> treat perivascular spasm
–> anti-hypertensive
–> use in visceral ischemia
–> relaxation of 3rd eyelid
–> Analeptic
Piperaxane
–> Non selective λ adrenergic blocking agent
–> decrease vasoconstriction
–> treat perivascular spasm
–> anti-hypertensive
–> use in visceral ischemia
–> relaxation of 3rd eyelid
Phenothiazine
–> Non selective λ adrenergic blocking agent
–> decrease vasoconstriction
–> treat perivascular spasm
–> anti-hypertensive
–> use in visceral ischemia
–> relaxation of 3rd eyelid
Chlorpromazine
–> Non selective λ adrenergic blocking agent
–> decrease vasoconstriction
–> treat perivascular spasm
–> anti-hypertensive
–> use in visceral ischemia
–> relaxation of 3rd eyelid
–> Tranquilizers, phenothiazine derivates
–> block dopamine effects
–> Antipsychotics
–> Serotonin antagonist
–> Anti-emetic
Prazosine
–> Selective λ1 adrenergic blocking agent
–> anti-hypertensive
–> Peripheral vasodilator
–> use to reduce effect of heart failure
Trimazosine
–> Selective λ1 adrenergic blocking agent
–> Anti-hypertensive
Atipamezole
–> Selective λ2 adrenergic blocking agent
–> Tranquilizers
Yohimbine
–> Selective λ2 adrenergic blocking agent
–> Tranquilizers, sedation, analgesia
Propanolol
–> Non selective β adrenergic blocking agent
–> anti-arrythmic
–> anti-hypertensive
–> obstructive heart disease
–> use in myocardial infarct risk
Pronethalol
–> Non selective β adrenergic blocking agent
–> anti-arrythmic
–> anti-hypertensive
–> obstructive heart disease
–> use in myocardial infarct risk