Pharmacology of Asthma Flashcards Preview

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Flashcards in Pharmacology of Asthma Deck (9):
1

Isoproterenol

Type
Action
Adverse Effect
Delivery

Nonspecific beta agonist

Relaxes bronchial smooth muscle (B2). Major adverse effect is tachycardia due to B1 stimulation

We give this through IV

2

Albuterol

Type
Action
Delivery

Specific B2 agonist

Relaxes bronchial smooth muscle B2. Use during acute asthma exacerbation.

Give via MDI or nebulizer

3

Salmeterol

Type
Action
Adverse Effect
Delivery

Specific B2 agonist

Long acting agent for prophylaxis. Adverse effects are tremor and arrhythmia

MDI or nebulizer

4

Theophylline

Type
Action
Adverse Effect
Delivery

Methylxanthine

Causes bronchodilation by inhibiting phosphodiesterase, thereby decreasing cAMP hydrolysis. Usage is limited because of narrow therapeutic index (abd pain, vomiting, seizures)

PO

5

Ipratropium

Type
Action
Delivery

Muscarinic antagonists

Competitive block of muscarinic receptors, preventing bronchoconstriction

MDI or nebulizer

6

Fluticasone, Beclomethasone, Prednisone

Type
Action
Adverse Effects
Delivery

Corticosteroids

Inhibit the synthesis of virtually all cytokines inactivates nf-kB which is the transcription factor that induces the production of TNF-a among other inflammatory agents. These can cause oral candidiasis, use mouthwash.

This is a first-line therapy for chronic asthma

MDI, nasal spray, or PO

7

Cromolyn, nedocromil

Type
Action
Delivery

Mast cell stabilizers

Prevent release of mediators from mast cells. Effective only for the prophylaxis of asthma. Not effective during an acute asthma attack.

MDI or nebulizer

8

Zileuton

Type
Action
Delivery

Antileukotriene

5-lipoxygenase inhibitor. Blocks conversion of arachidonic acid to leukotrienes

PO

9

Zafirlukast, Montelukast

Type
Action
Delivery

Antileukotriene

Block CysLT1 leukotriene receptors. Especially good for aspirin-induced asthma

PO