Pharmacology of Glucocorticoids Flashcards Preview

Endo/Repro Exam 1 > Pharmacology of Glucocorticoids > Flashcards

Flashcards in Pharmacology of Glucocorticoids Deck (20):
1

Mineralocorticoid:

Aldosterone

2

Synthesis inhibitor drugs:

Aminoglutethimide
Abiraterone
Metyrapone
Ketoconazole

3

What does Aminoglutethimide inhibit?

Pregnenolone synthesis

4

What does Aminoglutethimide inhibit?

Pregnenolone synthesis

5

What does ketoconazole inhibit?

Side chain synthesis

6

What does Metyrapone inhibit?

11-hydroxylation

7

What is mifepristone?

Steroid receptor inhibitor

8

What is mifepristone?

Steroid receptor inhibitor

9

Natural glucocorticoids:

Hydrocortisone

10

Mineralocorticoids:

Deoxycorticosterone
Fludrocortisone

11

Inhaled glucocorticoids:

Fluticasone
Budesonide

12

Inhaled glucocorticoids:

Fluticasone
Budesonide

13

Addison's disease replacement therapy acute and long term?

Acute:
A.) hydrocortisone
B.) hydrocortisone + fludrocortisone
Chronic therapy:
Hydrocortisone with increase dosage for times of physical stress

14

What is used in therapy for aldosterone deficiency?

Fludrocortisone

15

What does Aminoglutethimide do?

Inhibit formation of Pregnenolone from cholesterol

16

What is Aminoglutethimide used to treat?

Inhibitor therapy for estrogen-sensitive breast cancer

17

What is Abiraterone used to treat?

Refractory prostate cancer

18

What is the only drug for Cushing syndrome pregnancy use?

Metyrapone

19

What is ketoconazole used to treat?

Cushing syndrome

20

Mifepristone uses?

Cushing syndrome
Morning after pill
Anti-androgen