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Week 47: Osteoporosis > Pharmacology of Osteoporosis > Flashcards

Flashcards in Pharmacology of Osteoporosis Deck (10)
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1

Fragility fracture definition

Fracture that occurs spontaneously or following a minor trauma such as:
A fall from standing height or less
Fall from sitting
Fall from supine
Fall after missing 1-3 steps
After a movement outside the typical plane of motion or coughing

2

Who is high risk automatically?

Hip fracture
1 or more vertebral fractures
2 or more non-vertebral, non-hip fractures

3

Mild or unavoidable side effects of bisphosphonates

GI (take on an empty stomach, no food for 30-60 mins, remain upright)
Acute phase rxn (flu like sx)
Hypocalcemia
MSK pain

4

Adverse effects of bisphosphonates

Iritis/uveitis/conjunctivitis
Afib
Esophageal cancer
Jaw osteonecrosis
Atypical femur fractures

5

3 benefits and 3 risks to bisphosphonates

Benefits: vertebral fracture reduction, non vertebral fracture reduction, mortality reduction
Risks: osteonecrosis of the jaw, atypical femoral fracture, esophageal cancer

6

Adverse effects of denosumab

Eczema
Cellulitis
Flatulence
Hypocalcemia
ONJ and atypical fractures

7

Chronic PTH elevation effects

Increases osteoclast activation vis RANK/RANKL
Bone resorption

8

Intermittent PTH exposure

Promotes osteoblast activation
Anabolic effect

9

Romosozumab

Sclerostin antibody
Increases bone formation and decreases bone resorption

10

Strontium ranelate

Increases bone formation and decreases resorption