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Week 47: Osteoporosis > Pharmacology Special Cases > Flashcards

Flashcards in Pharmacology Special Cases Deck (6)
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1

Theoretical role of using anabolic followed by anti resorptive

Pros: build up more bone, earlier fracture prevention
Cons: side effects, cost

2

Role of androgens in male bone homeostasis

Account for larger peak bone mass in men than in women
Responsible for periosteal bone formation
Deficiency results in reduced bone width and formation

3

Pagets disease pathology

Osteoclasts increased in number and size
Overactive osteoblasts
Accelerated bone turnover
Matrix is disorganized
Bone size increased but more brittle

4

Clinical manifestations of paget's

Bone pain (unrelenting, worse at night, osteoarthritis)
Neurologic complication/compression
Bone deformity
Fracture
Osteosarcoma

5

2 situations where you should consider a drug holiday

Patients discontinuing GCs
Those who should not have been started on treatment in the first place (low fracture risk)

6

No drug holiday for what 4 meds

HRT
SERMs
Teriparatide
Denosumab