Pharmacology of Peripheral Neural Transmission

Question 1

α-latrotoxin

Answer 1

Binds neurexins

Question 2

α-methyldopa

Answer 2

α adrenoceptor agonist
(α1 < NA)
(α2 > NA)

Question 3

Amitriptyline

Answer 3

Uptake 1 inhibitor

Tricyclic antidepressant

Question 4

Atenolol

Answer 4

Selective β1 R antagonist

Question 5

Adenosine triphosphate

Answer 5

Purinoceptor agonist

Question 6

Atracurium

Answer 6

Competitive NMJ nicotinic cholinergic R agonist

Question 7

Atropine

Answer 7

Non-selective muscarinic cholinergic R antagonist

Question 8

Bethanechol

Answer 8

Non-selective muscarinic cholinergic R agonist

Question 9

Botulinum toxins

Answer 9

SNARE proteins inhibitor

Question 10

β-bungarotoxin

Answer 10

Acetylcholine vesicle release inhibitor

Question 11

Butaxamine/butoxamine

Answer 11

Selective β2 adrenoceptor antagonist

Question 12

Caffeine

Answer 12

Non-selective A1 & A2 R antagonist

Question 13

Carbidopa

Answer 13

DOPA decarboxylase inhibitor

Question 14

Clonidine

Answer 14

α (2 > 1) adrenoceptoragonist

Question 15

Clorgiline

Answer 15

Selective monoamine oxidase A inhibitor

Question 16

Cocaine

Answer 16

Uptake 1 inhibitor

Question 17

D-amphetaime/dexamphetamine

Answer 17

Displaces NA from vesicles
Adrenoceptor agonist
Competes for uptake 1
Weak MAO I

Question 18

Darifeneacin

Answer 18

Selective M3 muscarinic cholinergic R antagonist

Question 19

Dipyridamole

Answer 19

Type V phosphodiesterase

Blocks adenosine reuptake

Question 20

Dobutamine

Answer 20

Selective β1 adrenoceptor agonist

Question 21

D-tubocurarine/curare/tubocurarine

Answer 21

Non-selective nicotinic cholinergic R antagonist

Question 22

Dyflos

Answer 22

Irreversible, long lasting cholinesterase inhibitor

Question 23

Edrophonium

Answer 23

Reversible, short acting cholinesterase inhibitor

Question 24

Entacapone

Answer 24

Catechol o-methyltransferase (COMT) inhibitor

Question 25

Guanethidine

Answer 25

Competitive uptake 1 inhibitor

Question 26

Hemicholinium

Answer 26

Choline uptake inhibitor

Question 27

Hexamethonium

Answer 27

Non-selective ganglion blocker

Question 28

Idazoxan

Answer 28

Selective α2 adrenoceptor antagonist

Question 29

Imipramine

Answer 29

Uptake 1 blocker | Tricyclic antidepressant

Question 30

Isoprenaline

Answer 30

Non-selective β-adrenoceptor agonist | 10x > A

Question 31

Labetalol

Answer 31

Non-selective α1 & β adrenoceptor antagonist | α1 < β

Question 32

L-NMMA

Answer 32

Non-selective nitric oxide synthase inhibitor

Question 33

Malathion

Answer 33

Irreversible, long acting cholinesterase inhibitor

Question 34

Mecamylamine

Answer 34

Non-selective, ganglion nicotinic cholinergic R antagonist of the open channel (use-dependent)

Question 35

Muscarine

Answer 35

Muscarinic cholinergic R agonist

Question 36

Neostigmine

Answer 36

Reversible cholinesterase inhibitor

Question 37

Nicotine

Answer 37

Nicotinic cholinergic R agonist | ganglia > NMJ

Question 38

Nitroglycerin

Answer 38

Nitrovasodilator

Question 39

Pancuronium

Answer 39

Competitive NMJ nicotinic cholinergic R antagonist

Question 40

Phentolamine

Answer 40

Non-selective α1 & β1 adrenoceptor

Question 41

Phenylephrine

Answer 41

α1 & β1 adrenoceptor agonist | α1 >> β1

Question 42

Pilocarpine

Answer 42

Non-selective muscarinic cholinergic R agonist

Question 43

Pralidoxime

Answer 43

Reverses acetyl cholinesterase inhibition

Question 44

Prazosin

Answer 44

Selective α1 adrenoceptor antagonist

Question 45

Propranolol

Answer 45

β-blocker

Question 46

Reserpine

Answer 46

Vesicular monoamine transport 2 inhibitor

Question 47

Salbutamol

Answer 47

Selective β2 adrenoceptor agonist

Question 48

Selegiline

Answer 48

Monoamine oxidase B inhibitor

Question 49

Sildenafil

Answer 49

Phosphodiesterase V inhibitor

Question 50

Suxamethonium

Answer 50

NMJ nicotinic cholinergic R antagonist

Question 51

Tetanus toxin

Answer 51

Synaptobrevin inhibitor

Question 52

Tranylcypromine

Answer 52

Non-selective monoamine oxidase inhibitor

Question 53

Tyramine

Answer 53

Displaces NA from the vesicle | Adrenoceptor agonist

Question 54

Vesamicol

Answer 54

Non-competitive, reversible acetylcholine transporter into the vesicle inhibitor

Question 55

Xylazine

Answer 55

Selective α2 adrenoceptor agonist