Pharmacology of peripheral neurotransmission

Question 1

Triethylcholine

Answer 1

Competitive substrate for choline acetyl trasferase

Makes false transmitter

Question 2

Vesamicol

Answer 2

Inhibits vAChT for loading ACh into vesicles

Question 3

alpha-bungarotoxin

Answer 3

binds nAChR at NMJ (not at ganglion) to block

Irreversible

Question 4

beta-bungarotoxin

Answer 4

blocks ACh release via structural changes to pre-synaptic terminal

Question 5

alpha latrotoxin

Answer 5

forms pre-synaptic Ca2+ channels

Increases ACh release

Question 6

Trimethapham

Answer 6

competitive antagonist of nerve nAChR

Question 7

Hexamethonium

Answer 7

use dependent antagonist of nerve nAChR

Question 8

Suxamethonium

Answer 8

NMJ nM agonist (causes block) for tracheal intubation

Question 9

Decamethonium

Answer 9

Depolarising blocker of NMJ nM

Question 10

Curare and alpha bungarotoxin

Answer 10

NMJ nM antagonist to cause non-depolarising block and flaccid paralysis

Question 11

Tetracycline

Answer 11

Chelates Ca2+ to inhibit NMJ

Question 12

Aminoglycosides

Answer 12

Inhibit CaV to decrease ACh

Question 13

BoTX

Answer 13

Cleaves synaptobrevin at NMJ cholinergic neutrons

Question 14

TeNT

Answer 14

Cleaves synaptobrevin at inhibitory interneurons in CNS

Question 15

Edrophonium

Answer 15

AChE used to diagnose myasthenia gravid and treat glaucoma

Question 16

Neostigmine

Answer 16

AChE used to treat myasthenia gravis

Question 17

Rivastigmine

Answer 17

Anticholinesterase

To treat Alzheimers

Question 18

Sarin/Novichok

Answer 18

Irreversible AChE
Use atropine as antidote to cause tachycardia (via blocking M2 stimulation on the heart) and Pralidoxime to regenerating cholinesterase

Question 19

Bethanechol

Answer 19

ACh agonist to stimulate detrusor muscle via M3

Question 20

Pilocarpine

Answer 20

ACh agonist used to increase salivation and lacrimal secretion via action on M3

Question 21

Atropine

Answer 21

Blocks M2 stimulation on heart to treat bradycardia

Question 22

Ipratropium

Answer 22

Blocks M2 stimulation in asthma

Question 23

Tropicamide

Answer 23

Blocks M3 stimulation on pupil to cause dilation (mydriasis)

Question 24

Solifenacin

Answer 24

M3 selective blocker to inhibit detrusor contraction

Question 25

Glycopyronium

Answer 25

Blocks M3 to stop excessive drooling

Question 26

Phenylephrine

Answer 26

alpha1 selective agonist | Causes mydriasis and nasal decongestion

Question 27

Clonidine

Answer 27

alpha2 selective agonist to inhibit transmitter reease | - Reduces BP

Question 28

alpha-methyl DOPA

Answer 28

false transmitter with alpha2 selectivity

Question 29

Isoprenaline

Answer 29

beta agonist Bronchodilation via B2 Increased heart rate via B1

Question 30

Dobutamine

Answer 30

beta1 agonist to increase CO

Question 31

Salbutamol

Answer 31

beta2 agonist to relieve bronchospasm

Question 32

Mirabegran

Answer 32

beta2 agonist to relax detrusor

Question 33

Prazosin

Answer 33

alpha1 antagonist for treating hypertension

Question 34

Yohimbine

Answer 34

alpha2 antagonist to reverse veterinary sedation

Question 35

Propanolol

Answer 35

beta antaongist to decrease HR

Question 36

Atenolol

Answer 36

beta1 selective antagonist to treat hypertension

Question 37

alpha methyl tyrosine

Answer 37

pseudo substrate for TOH (rate limiting step of catecholamine synthesis)

Question 38

Carbidopa

Answer 38

inhibits dopa decarboxylase

Question 39

methyldopa

Answer 39

converted to false transmitter with highest affinity for pre-synaptic alpha2 recpetors

Question 40

Reserpine

Answer 40

irreversibly binds VMAT2 to block uptake of catecholamines to load vesicles

Question 41

Tetrabenzamine

Answer 41

reversibly binds VMAT2 | Used in Huntington's

Question 42

Guanethidine

Answer 42

taken into nerves by NET and vesicles by VMAT2, depleting it of NA Causes HR to fall

Question 43

Dexamfetamine

Answer 43

taken into nerves by NET and into vesicles by VMAT2, in exchange for NA which leaks out so promotes release

Question 44

Ephidrine

Answer 44

indirectly causes NA release and acts on post synaptic receptors Nasal decongestant

Question 45

Tricyclic antidepressants and cocaine

Answer 45

Block high affinity low capacity uptake 1 using NET

Question 46

Steroid hormone blocking uptake

Answer 46

Blocks uptake 2 using EMT

Question 47

Phenoxybenzamine

Answer 47

alpha antagonist to counteract large Adr released during adrenal gland removal