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HNN Week 4 > Pharmacology & the CNS > Flashcards

Flashcards in Pharmacology & the CNS Deck (15)
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1

ILO1

State the ways in which a drug can act in the CNS (i.e on the receptor themselves

Agonist - Activates receptor, produces functional response in cell

Antagonist - inhibits receptor by bindng to it, blocks agonist binding 

Partial Agonist - partially activates a receptor, producing lesser functional response

2

ILO1- Moa of CNS drugs

State ways in which a drug can affect enzymes and ion channels in the CNS

 

Enzymes: Can inhibit their action. Could argue some drugs may indirectly potentiate an enzyme as well, via agonistic mechanisms.

Ion channels: Can open ion channels, allowing more ions through the target channel, can also act as a blocker, reducing the ion flow. Most drugs block ion flow.

3

What chemical property is important for allowing drugs to reach the CNS

Lipophillic

4

State routes of drug delivery to the CNS, and explain what they are

 

  • Enteral (i.e by GI), lipophylic drugs
  • Parenternal (administered or occurring elsewhere in the body than the mouth and alimentary canal.)
  • Intrathecal (injection in the subarachnoid space)

5

State examples of paraenternal routes of drug administration for the CNS

Intravenous

Intramuscular

6

Give examples of classes of drugs tha that can be given intrathecally

 

  • Antibiotics (meningitis)
  • Chemotherapy
  • Anti-spasmodics

7

What structure severly restricts the subsatnces that can cross into the brain

BBB

8

State functions of the BBB

 

  • Prevent brain from foreign substances
  • Prevent peripheral neurotransmitters entering the brain
  • Maintain a constant biochemical and immunological environment for brain structures

9

State the key components for the BBB

 

Endotliel cells

Basement membrane

Astrocyte end foots

Pericytes

10

What structure holds the endothelial cells of the BBB together

Tight junctions

11

State diseases/conditions that can damage the BBB, and the conseqeunces of this

  • Hypertension
  • Infection
  • Trauma
  • Dangerous substances can enter the brain via a damaged BBB

12

What glucose transporter transports glcose across the BBB?

Glut-1

13

Certain patients have mutations in Glut1 where they cannot transport glucose across the BBB. How do levels of glucose differ between the CSF and blood? Non-pharmacological treatment for this?

Glucose is high in blood, low in CSF.

Ketogenic diet

14

State examples of neurotransmitters

 

GABA

Glutamate

Acetylcholine

Adrenaline

noradrenaline

Serotonin

Dopamine 

15

MIND MAP FOR NEUROTRANSMITTERS