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PRELIMS > PHCP - ENDOCRINE > Flashcards

PHCP - ENDOCRINE Flashcards

1
Q

responsible for normalized growth

A

Thyroid

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2
Q

Main component of Thyroid

A

Iodine

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3
Q

responsible for bone regulation - calcium

A

Calcitonin

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4
Q

Ratio of T4:T3

A

13:1

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5
Q

is an effective means of rejecting the large quantities of iodide and therefore preventing the thyroid from synthesizing large quantities of thyroid hormones.

A

Wolff-Chaikoff effect

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6
Q

Thioamides example

A

PTU, methimazole

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7
Q

MIT + DIT =

A

T3

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8
Q

DIT + DIT

A

T4

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9
Q

process where T4 is converted to T3

A

DEIONIZATION

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10
Q

Enzyme involved in DEIONIZATION

A

5’ deiodinase

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11
Q

Oncogene fam Includes

A

steroid hormones receptor

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12
Q

T_ resp for metabolism

A

T3

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13
Q

Disease associated with Hyperthyroidism

A

Grave’s disease

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14
Q

Disease associated with Hypothyroidism

A

Hashimoto Disease

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15
Q

Hypothyroidism
Adult Disease

A

Mixed edema

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16
Q

Hypothyroidism
Infant Disease

A

Cretinism

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17
Q

Used for Thyrotoxicosis

A

Propylthiouracil (PTU)
Methimazole

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18
Q

Methimazole is __x more potent than Propylthiouracil

A

10x

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19
Q

DOC for Thyrotoxicosis in Adult and Children

A

Methimazole

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20
Q

ADR of Methimazole

A

cholestatic jaundice

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21
Q

PTU black box warning:

A

severe hepatitis

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22
Q

Fetal ADR for thionamides

A

agranulocytosis

23
Q

INH of organification and hormone release * used in surgical thyrodectony

A

Iodide

24
Q

Adrenergeric Blockers - w/o _________

A

(ESA)
EXTRINSIC SYMPATHOMIMETIC ACTIVITY

25
Q

release beta-rays

A

RAI

26
Q

Liothyronine HALF LIFE

A

24h t1/2

27
Q

Hypersensitivity Type 1

A

Allergic Reaction / Immediate Hypersensitivity

28
Q

Hypersensitivity Type 2

A

CYTOTOXIC RXN

29
Q

Hypersensitivity Type 3

A

IMMUNE COMPLEX RXN

30
Q

Hypersensitivity Type 4

A

DELAYED HYPERSENSITIVITY

31
Q

IGE, mast cell, basophil; within 1hr

A

Type 1

32
Q

Examples: bee sting, latex allergy, medications (penicillin), urticaria, anaphylaxis, atopy (allergic rhinitis, asthma, atopic dermatitis or eczema)

A

Type 1

33
Q

IgB, IgM; Hours to Days

A

Type 2

34
Q

Igb, IgM; 1-3 weeks

A

Type 3

35
Q

Examples: Hemolytic rxn w/meds, graft rejections

A

Type 2

36
Q

Examples: SLE, serum sickness

A

Type 3

37
Q

Examples: Mantoux test (PDD) (10-15MM) AKA MENDEL MANTOUX TEST
-Nickel Allergy, SJS, Poison Ivy (Uroshiol)

A

Type 4

38
Q

serves as scaffold for thyroid hormone
synthesis

A

Thyroglobulin

39
Q
  • formation of MIT
    (monoiodotyrosine) and DIT (diiodotyrosine)
A

Iodine organification

40
Q

of thyroglobulin liberates the T3 and T4 in
the blood

A

Proteolysis

41
Q

Most thyroid hormone is transported by ______ . Prealbumin and albumin
also serves as carriers.

A

THYROXINEBINDING GLOBULIN (TBG)

42
Q

Heat intolerant
Pale edema, exopthalmos
Palpitation, tachycardia

A

Hyperthyroidism

43
Q

Difficulty in breathing
Inc appetite, loss weight,
diarrhea
Tremor, Nervousness,
menstrual irregularity
Extreme muscle weakness

A

Hyperthyroidism

44
Q

Polyuria
Anemia
Dysmenorrhea,
amenorrhea
Inc basal metabolic rate,
hyperglycemia

A

Hyperthyroidism

45
Q

Cold intolerant
Drooping eyelid
Bradycardia
Hypoventilation and CO2
retention

A

Hypothyroidism

46
Q

Dec appetite, weight gain,
constipation
Lethargy, stiffness,
infertility
Excessive muscle
contraction

A

Hypothyroidism

47
Q

Urinary retention
Anemia (most common)
menorrhagia
Dec basal metabolic rate,
hyperlipidemia

A

Hypothyroidism

48
Q

It is the clinical syndrome
that results when tissues
are exposed to high levels
of thyroid hormone

A

Hyperthyroidism

49
Q

– AKA
thyrotoxic crisis

A

– Thyroid Storm

50
Q

– this test can see if your
thyroid gland has any nodules.

A
  • Thyroid ultrasound –
51
Q

– this test uses a radioactive
substance to make an image of the thyroid.

A

Thyroid scan –

52
Q

measure the amount of thyroid
hormone and thyroid stimulating hormone in
your blood.

A

Blood tests –

53
Q

Block thyroid hormone
synthesis by inhibition of
peroxidase enzyme

A

Thioureas (Thionamides)

PRELIMS (13 decks)

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