Physiochemical Factors Affecting Bioavailability

Question 1

List the physiochemical factors affecting bioavailability

Answer 1

Question 2

Define drug solubility and its impact of bioavailability

Answer 2

Question 3

List the factors affecting drug solubility

Answer 3

Question 4

Explain how pH and ionization affects drug solubility

Answer 4

Question 5

Explain how salt formulation affects drug solubility

Answer 5

Question 6

Explain how polymorphism and crystal forms affect drug solubility

Answer 6

Question 7

Explain how co solvents and surfactants affect drug solubility with example

Answer 7

Question 8

Define dissolution

Answer 8

Question 9

What are the factors affecting drug dissolution

Answer 9

Question 10

Explain how particle size affects dissolution rate with example

Answer 10

Question 11

Explain how diffusion layer thickness affects dissolution rate with example

Answer 11

Question 12

Explain how salt form of the drug affects dissolution rate with example

Answer 12

Question 13

Exp,son how surfactants affect dissolution rate with example

Answer 13

Question 14

Explain lipophilicity and partition coefficient affecting bioavailability with example

Answer 14

Question 15

Explain how drug ionization affects bioavailability with example

Answer 15

Question 16

Exp,son how molecular size and shape affects bioavailability with example

Answer 16

Question 17

Explain how drug stability in GI fluids affects bioavailability with example

Answer 17

Question 18

What are the optimization strategies for bioavailability

Answer 18