Physiology

Question 1

High risk for re-feeding syndrome factors

Answer 1

BMI < 16
Unintentional weight loss >15% over 3-6 months
Reduce nutritional intake >10days
HypoK,phos,Mg prior to feeding - e.g. Diuretics

Hx of ETOH abuse, insulin, chemo, diuretics, antacids

Question 2

Stress response effects

Answer 2

Substrate mobilisation, Muscle protein degradation, suppression of anabolic hormone secretion (GH, insulin, testosterone), activation of SNS, immunological and haematological changes

Question 3

Hormones that are increased in the stress response

Answer 3

Growth hormones, Cortisol, Renin, ACTH, Aldosterone, Prolactin, ADH, Glucagon

Question 4

What are mesangial cells and what is their function

Answer 4

Contractile cells that are located in the tubule. They will secrete aldosterone when systolic <65mmHg

Question 5

What is the MOA of cortisol physiologically

Answer 5

Made from cholesterol in the adrenal cortex, it binds to intracellular receptors that migrate to the nucleus to affect gene transcription