Physiology of Infection Flashcards Preview

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Flashcards in Physiology of Infection Deck (23):
1

Forgotten factors increasing susceptibility

Deficiencies
High alcohol consumption

IFN gamma deficient
TNF alpha genes

2

Factors affecting severity

Inflammation
Coagulopathy
Organ damage

3

LPS constituents

Lipid A
Saccharide middle
O antigen polysaccharide

4

Virulence factors

Biofilm
Toxins
Superantigens
Panton Valentine leucocidin

5

Vector req virus

Rabies

6

Epithelial colonisation forgotten means

Pili + fimbriae
Binding of human receptors
Cell internalisation
Cell penetration
Desmosome cleavage (scalded skin)

7

Superantigen effects

Hyperactivates T cells via MHCII linking
Excess inflammatory mediators + TNFa
Diverts Th1 response

8

Define sepsis

Life-threatening organ dysfunction secondary to infection

9

Sepsis management

ITU
Debridement
IgG transfusion
Antitoxins
Blood
Fluid
Antibiotics
Inotropes

10

Key Strep A organism

S pyogenes

SpyCEP cleaves IL8

11

Sepsis pathogenesis

Inflammation
Endothelial dysfunction
Mitochondrial problems
Clots
Organ failure

12

Forgotten innate immune system

Microbiome competition
CRP

13

NK cells stimulation

IL12+15
Inhibited by ITIM
Activated by Syk

14

Opsonisation

Requires complement + antibody

15

Key cytokines

Inflammatory: TNFalpha, IL1

Regulatory: TNF gamma, IL12

Down regulatory: IL10, TGF

16

Recall complement pathways

Alternative - pathogen
Classical - Ab
Lectin - MBL

17

Forgotten neutrophil armoury

Elastase, cathelicidins

18

Th1, 2, 17

Th1 = macrophage activation

Th2 = basophil

Th17 = neutrophil

19

Secreted effectors

Mucin
Lactoferrin
Defensins
Lysozyme

20

Complement for what type

Gram negative mainly, phagocytosis for positive

21

C. difficile

Toxin A, B
Endospores
Gram positive

Pseudomembranous colitis; perforation

Metronidazole

22

S aureus

Inhibits complement + neutrophils
Uses PV leucocidin
Superantigens
Biofilm - végétations
TSST1

Gram positive, catalase positive clusters

Rifampicin

23

S pneumoniae

Pneumolysin, autolysin
Capsule
Spores

Gram positive, catalase negative chains


Clindamycin