Pick Doxycycline (Tick Illnesses Lec 4) Flashcards

(48 cards)

1
Q

What is the vector for Lyme disease?

A

Ixodes tick (aka hard-bodied tick/deer tick/blacklegged tick)

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2
Q

2 general locations that Lyme disease is found in the US

A

Upper midwest and Northeast

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3
Q

Classic characteristic of disseminated lyme disease:

A

cranial neuritis (CN7 Palsy)

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4
Q

Joint problems associated with Lyme disease:
____ is seen in stage 2
_____ is seen in stage 3

A

Arthralgias

Arthritis, esp in knee

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5
Q

Cardiac problem associated with Lyme:

A

AV nodal block

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6
Q

DDx of CN7 palsy, besides Lyme:

A

Bell’s Palsy (most common; idiopathic)
HSV (no rash)
Herpes-Zoster (vesicles in audtiory canal)

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7
Q

Treatment of Lyme disease:

A

Doxycycline (sometimes ceftriaxone)

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8
Q

What bacteria causes Rocky Mountain Spotted Fever?

A

Rickettsia Rickettsii

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9
Q

R. Rickettsii has a trophism for ________

A

vascular endothelial cells

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10
Q

Vector for RMSF

A

american dog tick

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11
Q

Location RMSF is seen:

A

Upper SE US ie NC, TN

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12
Q

_______ and _______ are common pathophysiologic findings of RMSF. They are caused by an increased vascular permeability due to _____

A

hyponatremia, thrombocytopenia; vasculitis

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13
Q

Describe the rash of RMSF:

A

faint macules progressing to a vasculitic rash and petechiae;
may involve palms and soles!

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14
Q

Do the lesions in RMSF blanch?

A

no

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15
Q

Elevated ______ seen in RMSF may indicate liver failure

A

transaminases

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16
Q

2 main disease to think of in patient presenting w/ fever + petechial rash on palms and soles:
Thus, treatment should be ________

A

meningococcal disease and RMSF

Ceftriaxone and doxy

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17
Q

_____ may be given to pregnant patients with RMSF

A

Chloramphenicol

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18
Q

Bacterial organism causing Ehrlichiosis:

A

Ehrlichia chaffeensis

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19
Q

Vector for Ehrlichiosis:

A

Lone star tick

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20
Q

Symptoms of Ehrliciosis/Anaplasmosis: (3)

____ is rare

A

fever, headaches, myalgias;

rash

21
Q

Treatment for ehrliciosis/anaplasmosis =

22
Q

Lab findings of Ehrliciosis/Anaplasmosis = (3)

A

Leukopenia, Thrombocytopenia, Elevated transaminase

23
Q

Where is ehrliciosis common?

24
Q

Where is anaplasmosis common?

A

Upper MW and NE

25
What bacteria causes anaplasmosis?
Anaplasma phagocytophilum
26
Vector for anaplasmosis: | Co-infection with _____ is common
Ixodes tick | Lyme disease
27
Causative organism of Malaria:
Plasmodium species
28
Vector of malaria:
anopheles mosquito
29
_____ reproduction of plasmodium occurs in human hepatocytes
asexual
30
______ can produce dormant hypnozoites in hepatocytes, which can reactivate in 3-12 months
P vivax/P ovale
31
The most severe of the plasmodium species is ______
Plasmodium falciparum
32
P. malarie has a ______ cycle; ie fevers are _____ hrs apart
quartan; 72
33
P vivax and P ovale have a _____ cycle; ie fevers are ___ hrs apart
tertian; 48
34
plasmodium _____ have a trophism for hepatocytes
sporozoites
35
Seizures suggest infection caused by plasmodium _____
falciparum
36
Paroxysmal chills, fever, and rigors suggest infection caused by plasmodium _____ or _____
vivax/ovale typically; also malariae
37
Cardinal symptom in malarial infections
fever
38
____ is very unusual in malaria
rash
39
P falciparum can cause _____ and _____ in vasculature, including the CNS
sequestration, agglutination
40
_____ is a poor prognostic sign in P falciparum. It is due to decreased _____ gluconeogenesis
hyopglycemia | hepatic
41
Metabolic ______ can occur in P falciparum
acidosis
42
Blood vessel occlusion can classically affect these 2 organs:
kidneys, lungs
43
What kind of blood smears are used to diagnose Malaria? Evaluating for?
thick and thin; | ring forms
44
For non Falciparum malaria, ___ is the treatment of choice in sensitive patients
chloroquine
45
For falciprum, _____-based combos are preferred
arteminsin
46
_____ has the shortest lead up and follow up of anti-malarial drugs used in travelers and is preferred
Malarone
47
Malarone consists of ______
Atovaquine + Proguanil
48
_____ is typically avoided in malarial prophylaxis due to CNS side effects
mefloquine