Lecture 13 Vasculitis Flashcards
(61 cards)
Vasculitis is ____ of the blood vessel wall which can lead to _____ and _____
inflammation;
thrombus, fibrosis
Takayasu stereotypic patient:
Temporal/giant cell stereotypic patient:
asian females less than 40;
elderly females
2 large vessel vasculitis:
takayasu; temporal/giant cell
Takayasu classically causes _____ thickening and narrowing of the ____ ____ and proximal great vessels
granulomatous;
aortic arch
Takayasu is called ____ disease due to a blood pressure difference between the upper and lower extremities
pulseless
Treatment for both large vessel vasculitides:
high dose corticosteroids
Giant cell arteritis (GCA) typically affects branches of the ____ artery
carotid (ie temporal)
in GCA, temporal artery involvement causes ____;
opthalmic artery involvement can cause ____
headache, jaw claudication;
blindness/visual problems
GCA is associated with _______ _____, seen as flu-like symptoms, myalgia, and joint pain
polymyalgia rheumatica
The 2 large cell vasculitides present with _____ ESR
elevated
What kind of inflammation do GCA and takayasu show?
granulomatous
What are the 2 medium vessel vasculitides mentioned in the notes?
polyarteritis nodosum (PAN), kawasaki disease
What is the most commonly affected organ in PAN, and what are the characteristic findings?
Kidney–>hypertension, elevated BUN
If there is ischemia to the GI, symptoms such as ____ and ____ can occur
pain, melena
What is characteristically seropositive in PAN?>
HBSAg (hep b surface antigen)
treatment for PAN?
corticosteroids, cyclophosphamide
Kawasaki disease classically affects ____
asian kids less than 4 years
Most important artery that can be affected in kawasaki?
coronary artery
‘CRASH and burn’ symptoms associated with kawasaki:
Conjunctivitis, Rash, Adenopathy, Strawberry tongue (oral mucositis), Hand and foot rash, and Fever (high)
Treatment for kawasaki?
IV immunoglobulin and Aspirin
ANCA positive small vessel vasculitides?
microscopic polyangiitis, granulomatosis with polyangititis (wegener’s), eiosinophillic granulomatosis with polyangitis (churg strauss)
what immunoassay enzyme is associated with c-ANCA? what is the characteristic staining?
proteinase 3 (PR3); cytoplasmic
what immunoassay enzyme is associated with p-ANCA?; what is the characteristic staining?
myeloperoxidase (MPO); perinuclear
Memory hook for Wegener’s/granulomatosis with polyangiitis (GPA):
characterisitc areas affected:
“C” disease (from pathoma)
nasopharynx, lungs, kidneys
