PID/PCOS/ENDOMETRIOSUS Flashcards

(63 cards)

1
Q

ascending spread of microorganism and contiguous structures from vagina or cervix to endometrium, tubes, ovarious

A

PID

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2
Q

60% of PID is ___

A

subclinical or silent

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3
Q

examples of PID RF

A
adolescence  
GC or CHL or HX of GC/CT 
Multiple partners 
Inserting IUD 
Demographic SES  
Hx of PID 
Male Partners w/ GC or Chl 
BV 
OCP in some cases
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4
Q

top 2 most common pathogens with PID

A

N. gonorrhoeae

C. trachomatis

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5
Q

what are some sx women with subclinical PID may experience?

A
  1. dyspareunia
  2. irregular bleeding
  3. dysuria
  4. GI sx
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6
Q

what bacteria is implicated with subclinical PID presentation?

A

C. trachomatis

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7
Q

most common sign on pelvic exam in pt with moderate PID

A

uterine, cervical motion, and adnexal TTP

Chandelier sign

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8
Q

what s/s indicate severe PID

A

high WBC and ESR/CRP

very ill: fever, chills, purulent d/c, N/V

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9
Q

risk of ectopic pregnancy is __ higher after PID

A

6-10 times higher after PID

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10
Q

tubal infertility rates after __ episodes of PID

A

1: 8% of women
2: 20% of women
3: 50% of women

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11
Q

what is fitz hugh Curtis syndrome

A

RUQ pain associated with acute salpingitis

indicating perihepatitis

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12
Q

what is fitz hugh Curtis syndrome mistaken for?

A

acute cholecystitis may be suspected but signs of PID show up quickly

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13
Q

PID dx criteria

A

uterine TTP or cervical motion TTP (w/ no other explanation)

Other add on signs:

  1. temp 38.3
  2. abnormal discharge
  3. WBC on saline wet prep
    • Gonorrhea or chlamydia test

Mucopurulent Cervical discharge + test

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14
Q

5 reasons to admit PID pt

A
  1. cant r/o appendicitis ectopic
  2. Pregnancy
  3. No response to output antimicrobial tx 48-72 hrs
  4. severe illness (N/V, fever, TOA)
  5. HIV infxn with low CD4 count
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15
Q

1st line PID tx

A

ceftriaxone 250mg IM + doxy 100 mg BID for 14 days

OR

Ceftriaxone 250mg IM + Metronidazole 500mg BID X 14 days

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16
Q

if choosing cefoxitin instead of ceftriaxone what po med would you pair it with for PID tx

A

cefoxitin 2g IM + Probenecid 1 g PO administered
PLUS
doxy or metronidazole

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17
Q

parenteral PID tx

A

cefotetan 2gIV q 12 hr plus doxy

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18
Q

women with PID sex?

A

no wait until tx is done, sx resolved and partners are treated

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19
Q

all women with PID need to be tested for..

A

HIV, GC, HIV and Chl (NAAT)

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20
Q

PID pts should show improvement with tx in ___

A

72 hrs

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21
Q

all women dx with GC/Chl should be retested ____after tx regardless of whether their partner has been treated

A

3mo

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22
Q

all pregnant women in 1st trimester are screened for___

A

PID

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23
Q

when is screening for chlamydia recommended

A

all women that are active and under 25, and all those active over 25 that are high risk

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24
Q

t/f male partners of women with PID should be examined and tx if they had contact within 60 days prior to sx onset

A

true!

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25
male partners of PID women are often asymptomatic when the bacteria etiology is...
c trichamatis and N. gonorrhoaea
26
how treat PID sexual partners?
empirically for c. trachomatis or N. gonorrhoeae
27
t/f gonorrhea and chlamydial is reportable in all states
TRUE
28
3 main complications of pID
1. ectopic preg 2. chronic pelvic pain 3. Infertility
29
PCOS 3 main characteristics
hyperandrogenism ovulatory dysfunction polycystic ovaries
30
what are some secondary cause of hyperaldosteronism to r/o before dx PCOS
1. adult onset CAH 2. Hyperprolactinemia 3. Androgen secreting neoplasms
31
what is link between hyperinsulinemia and PCOS?
high levels of insulin in blood lead to low levels of sex hormone binding globulin this increases levels of free androgens = hyperadnrogenism
32
3 main U/s findings of PCOS
12+ follicles in each ovary follicles 2-9mm in diameter high ovarian volume over 10 mL
33
TX PCOS menstrual irregularities
1. Combined OCP 2. Progestins also option 3. Insulin Sensitizing agents
34
what DM meds good for PCOS
Biguanides (metformin) OR thiazolidinediones (pioglitazone, rosiglitazone)
35
what dose of combined OCP is best for PCOS?
low dose for insulin sensitivity etc
36
tx for hirsutism
laser therapy, combo therapies | medical methods will help as well - spironolactone with OCP
37
what OCP do you not want to give with spironolactone
one that contains drospirenone from spironolactone family as well.. retain too much K+?
38
how does spironolactone help with PCOS sx?
1. androgen receptor antagonist 2. competes for androgen receptors on follicles 3. inhibits 5 aphla reducatse
39
what does 5 alpha reducatase do?
converts testosterone into dihydrotestosterone
40
what is dihydrotestosterone?
DHT | Responsible for male sexual maturation and secondary sexual characteristics
41
what do flutamide and finasteride do for PCOS?
for hirsutism.. yet high risk of teratogenicity
42
Eflornithine role
FDA med for female facial hirsutism | ADR: stinging, burning, erythema,
43
is laser or electrolysis better for hirsutism?
laser therapy | adding eflornithine on top of laser is even better as well
44
benign condition, endometrial glands and stroma present outside uterus
endometriosus
45
typical endometriosus pt
30s, nulliparous, infertile but can present throughout reproductive yrs
46
endometriosus is found in ___ fraction of women with chronic pelvic pain
1/3
47
3 theories of endometriosus pathology
1. Retrograde menstration: fragments transport out via fallopian tubes during menses 2. Mullerian metaplasia theory: metaplastic transformation of pelvic peritoneum 3. lymphatic spread: substances released/shed from endometrial induce formation of endometriosus
48
what is sampsons therory
retrograde menstration - endometriosus
49
what is Meyers theory
mullerian or coelomic metaplasia theory for endometriosus
50
what is halbans theory
lymphatic spread theory of endometriosus
51
where is most common location of endometrial deposits?
ovary (chocolate cysts)
52
classic triad of endometriosus
dysmenorrhea, dyspareunia, dyschezia
53
DX of endometriosus
direct visualization: laparotomy or laproscopy | histologic and gross findings consisitent with dx
54
US findings for endometriosus
adnexal mass of complex echogenicty, internal echos consistent with blood
55
ca125 test
for endometriosus.. not sensitive or specific
56
1st line tx for endometriosus
NSAIDS, OCP, Progestins trial for 3-6mo
57
2nd line tx for endometriosus
levonorgestrel (mirena IUD), GnRH agonist (Lupron), high dose progestin, danazol
58
what is important about using Lupron for tx
do no give w/o laparoscopy first.. relief of pain does not make the dx ADR: hotflashes, bone loss, depression
59
what is danazol
2nd line tx option endometrioses | androgenic derivative suppresses LH and FSH
60
previously the gold standard for endometriosus
danazol not anymore due to ADR: weight gain, hirsutism, acne, deep voice, pseudomenopause - anovulation and hypergonadism
61
how to protect fertility for endometrioses pt
1. laparoscopic w/ ablation of implants / adhesions | 2. should remove endometrioses over 3 cm in diameter
62
most definitive tx endometrioses
hysterectomy ..yet still risk of reoccurrence
63
how decrease risk of endometrioses
min. menses flow and suppress ovarian cycling