Pigmented lesions Flashcards
(27 cards)
What hair colour does Phaeomelanin cause
red
What are actinic lentigines
age or liver spots
how are usual acquired nave formed
breakdown of melanocytes: keratinocyte ratio at a number of sites
how many nave does the average human have
20-30
What is junctional naevus
melanocytes cluster at DEJ
What is compound naevus
junctional and in dermis layer of melanocytes
What is intradermal naevus
no junctional activity, jus tin dermis
There is no familial risk of dysplastic naevi-> melanoma
False, there is up to a 100% chance
Is the epidermis affected in the dysplastic naevi
No
What is the Spitz nave
Benign, spindle/ epithelioid cell s. Mostly occurs in those under 20
What is the most common cause of malignant melanoma
sun exposure/ sunburnt as a child
What are signs of melanoma
bleeding, change in mole, change in colour, shape, ulceration
What is the commonest type of malignant melanoma
superficial spreading
what does VGP stand for
vertical growth phase
can VGP metastasis
YES
can RGP metastasis
No
melanoma
100%
melanoma >4mm has survival of
20%
what does the suffix b stand for
ulceration- a key factor in diagnosis
What is the treatment for melanoma
eliptical excision. Some may have a sentinel biopsy. If this is positive, lymphadenectomy. In advanced disease, chemo, radio, immunosup
what can ckit mutation melanomas be treated with
imatinib
where would you normally find a superficial spreading melanoma
trunk or legs
Is nodular melanoma thought to be the worst of them all?
Yup
Where does acral lentiginous melanoma affect
soles, nails or palms
