Skin pathology Flashcards
(36 cards)
where are melanocytes found
dermo-epidermal junction
what does the corneal layer consist of
differentiated keratinised cells
How do melanocytes transfer pigment
transfer pigment to keratinocytes via dendritic processes
where does the papillary dermis lay
below epidermis
What layer of the dermis contains appendage structures
reticular dermis
What is the basal membrane made from
laminin and collagen IV
What class of inflammatory skin disease is eczema?
Spongiotic- intraepiderma oedema
What type of inflam diseases is psoriasis
psoriasiform elongation of rete ridges
What is lichen plans or lupus
lichenoid- basal layer damage
What type of diseases is pemphigoid, pemphigus, dermatitis herpetiformis
Vesiculobullous- blistering
Where does psoriasis usually present
Extensors
Where does acne most commonly affect
face, back, chest
Why does acne occur
increase androgens during puberty, causes increase sebaceous gland activity. Causes keratin plugging of the pilosebaceous units and infection with corynebacterium acnes
What is rosacea
recurrent facial flushing with visible blood vessels
What can trigger rosacea
sunlight, alcohol, stress, spicy foods
What are the primary presentations of immunobullous disroders
Blisters
What is pemphigus
superficial blisters, IgG autoantibodies produced against desmoglein 3. Immune complexes form on cell surface, complement activation and protease release = acantholysis (breakdown of desmosomes/ connections)
When fluid filled blisters rupture what do they cause?
EROSIONS
Is a bullous pemphigoid superficial or deep?
DEEP
there is evidence of acantholysis in pemphigoid true or false
flase
How does pemphigoid arise
IgG reacts with antigens of hemidesmosomes anchoring basal cells to basement membrane. Complement activation and tissue damage
What disease is dermatitis herpetiformis associated with
coeliac disease
IS dermatitis herpetiformis itchy or nor?
SO ITCHY
Where does herpetiformis effect?
elbows, knees, buttocks
