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PKD Flashcards

1
Q

What is PKD

A

Cyst formation through renal parenchyma causing bilateral enlargement and damage

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2
Q

What are the causes of PKD

A

Aut Dominant mutation of PKD1/2

Aut Recessive mutation (Congenital dysfunction)

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3
Q

What does PKD1/2 do

A

Code for Polycystin/Ca Channels

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4
Q

What is the pathology of PKD

A

Decreased Calcium influx = less filtrate out = increased cilia growth = Csts

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5
Q

What happens normally at the cilia when filtrate passes

A

Polycystin open allowing calcium influx (letting filtrate out) and preventing excessive cilia growth

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6
Q

What is the presentation of PKD

A

Bilateral Flank/Abdo pain
HTN and Haematuria
Sub Arachnoid haemorrhage

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7
Q

Why may a Sub arachnoid haemorrhage appear with PKD

A

Extra renal cysts rupture berry aneurysm

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8
Q

How is PKD investigated

A 
Kidney USS (Enlarged bilateral kidneys w/ cysts)
Genetic tests
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9
Q

How is PKD Treated

A

Manage HTN and ESRF (Transplant and haemodialsysi)

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GU (10 decks)

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