Plant Alkaloids

Question 1

Extracts from Catharanthus roseus

Answer 1

Vincristine
Vinblastine
Vinrosidine
Vinorelbine
Vinleurosine

Question 2

Cancer treated by Vincristine and Vinblastine

Answer 2

Leukemia, Lymphoma, Testicular Cancer

Question 3

Vinca Alkaloids mechanism is common as

Answer 3

Colchicine, Podophyllotoxin, Taxanes , epothilones,.
Block cell proliferation in metastasis

Question 4

How Vincristine and Vinblastine act

Answer 4

Bind to tubulin, no microtubules, mitotic arrest, dissolution of Mitotic Spindle and interference with chromosome segregation

Question 5

Most important use Vincristine and Vinblastine

Answer 5

With bleomycin, Cisplatin for testicular therapy

Question 6

Other clinical uses of Vincristine and Vinblastine

Answer 6

Kaposi sarcoma, Hodgkin’s lymphoma neuroblastoma, breast and chorio carcinoma

Question 7

Toxicities of Plant alkaloids

Answer 7

Leukopenia, alopecia, GIT , dermatitis, myelo toxicity and neurotoxicity

Question 8

Gene responsible for resistance in plant alkaloids

Answer 8

MDR gene… And it’s glycoprotein…

Question 9

Paclitaxel is obtained from

Answer 9

Bark of western yew tree

Question 10

Anti tumor activity of paclitaxel is due to

Answer 10

Taxane ring as it’s nucleus

Question 11

MOA of paclitaxel

Answer 11

Antagonize the disassembly of microtubules by binding with the B-tubulin…

Question 12

Resistance to paclitaxel occur due to

Answer 12

Mdr-1 and p-glycoprotein…

Question 13

Therapeutic use of paclitaxel

Answer 13

Metastatic ovarian and breast cancer

Question 14

Toxicities of Paclitaxel

Answer 14

Bone marrow suppression, neutropenia, peripheral neuropathy, etoposide

Question 15

Etoposide blocks cell division in which phase

Answer 15

S and G 2 phase

Question 16

MOA of etoposide

Answer 16

Drug form tertiary complex with topoisomerase 2 and DNA…
Double strand DNA breakage

Question 17

Clinical use of etoposide

Answer 17

With bleomycin and Cisplatin
Testicular Cancer, non Hodgkin’s lymphoma, small cell lung cancer…

Question 18

Toxicities of Etoposide

Answer 18

Hypotension, bronchospasm,

Question 19

What is dactinomyocin

Answer 19

1st crystalline antibiotic species obtained from streptomyces

Question 20

MOA of dactinomyocin

Answer 20

Drug DNA complex inhibit transcription of DNA by blocking DNA dependent RNA polymerase

Question 21

How dactinomyocin is used for treatment of Wilm tumor and rhabdomyosarcoma

Answer 21

In combination with Vincristine and Cyclophosphamide

Question 22

Dactinomyocin toxicities

Answer 22

Hematopoietic suppression, pancytopenia, ulceration

Question 23

What is bleomycin

Answer 23

DNA Cleaving Group
Mixture of 2 copper chelating peptides
A2 and B2….

Question 24

MOA of bleomycin

Answer 24

Bind to DNA through it’s amino terminal peptide and activated free radicals cause DNA breakage

Question 25

Explain the mechanism of bleomycin

Answer 25

Oxidation of DNA-Bleomycin iron complex which act as ferrous oxidase.. It transfer electrons to molecular oxygen which lead to chromosomal aberrations

Question 26

Bleomycin effects which phase

Answer 26

G2

Question 27

Clinical use of bleomycin

Answer 27

Germ cell tumors of testis and ovaries with Cisplatin and Vinblastine

Question 28

WHAT IS ABVD

Answer 28

Adriamycin, bleomycin, Vinblastine, Dacarbazine

Question 29

ABVD is used for

Answer 29

Carcinoma of head, neck, Hodgkin's and non Hodgkin's, esophagus,

Question 30

Toxicities of ABVD

Answer 30

Hyperpigmentation, Hyperkeratosis, pulmonary toxicities and anorexia