Platelet Gel- Exam 3 Flashcards Preview

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Flashcards in Platelet Gel- Exam 3 Deck (55)
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1

Young, fecund, robust, inactivated platelets are _______ um discoids.

1-3

2

Humans: Normally how many platelets in blood?

150,000-300,000 / ul of blood

3

What is the life span of a platelet?

About a week

4

What do alpha granules contain?

Clotting factors, growth factors, and various other proteins

5

What do dense granules contain?

ADP, ATP, serotonin, calcium

6

How do young and old platelets compare?

Young platelets are large and heavy (dense)
Old platelets are small and light

7

Do young or old platelets aggregate faster? How much faster?

Young large platelets aggregate much faster; about 3-5x faster than older platelets

8

Do young or old platelets release more ATP? ADP?

Young platelets release more ATP (4-8x more)
Young platelets release more ADP (4-6x more)

9

Do young or old platelets require substantially greater amounts of ADP to be activated?

Older platelets require more ADP to be activated

10

What are the 3 phases that occur after tissue injury?

Primary Hemostasis
Secondary Hemostasis
Fibrinolysis

11

Primary Hemostasis

Vasoconstriction
Platelet adhesion
Platelet aggregation

12

Secondary Hemostasis

Activation coagulation factors
Fibrin formation

13

Fibrinolysis

Activation fibrinolytic system
Clot lysis

14

Fibrinolysis

Activation fibrinolytic system
Clot lysis

15

Wound --> Exposes what?

Subendothelial Collagen

16

When subendothelial collagen is exposed, what binds?

von Willebrand Factor

17

After vWF binds, platelet adhesion to blood vessel wall occurs via what?

Glycoprotein IIb/IIIa receptors

18

When platelet adhesion to blood vessel wall occurs, what happens next?

Platelet activation

19

What happens when platelets are activated?

Platelet cytoskeleton (via actin and myosin) expands to form a disc to a multi-pseudopodal sticky blob leading to platelet aggreagation

20

What does serotonin do?

vasoconstriction

21

What does ADP do?

Recruits other platelets to aggregate and degranulate

22

What does thromboxane do?

Platelet aggregation and PGF release

23

PDGF

Platelet Derived Growth Factor

24

What does PDGF do?

Strongly mitogenic and chemotactic for leukocytes
By itself, application doubles the rate of collagen deposition in a wound (plus a bunch of tother stuff that aggressively accelerates healing)

25

TGF-B

Transforming Growth Factor Beta

26

What does TGF-B do?

Also strongly mitogenic
Allows damaged (irradiated, corticosteroid-treated) tissues to revert to normalized collagen deposition

27

What do attracted neutrophils and macrophages release?

A host of other healing factors

28

Are granulocytes (neutrophils) good?

Good/bad/indifferent

29

Where are cells expressing CD34 protein concentrated?

IN the mononuclear layer of platelet concentrate

30

What are CD34 proteins?

Cells are stem cell "markers" and are important for other cells' adhesion/chemotaxis