Platelet transfusion

Question 1

What are the different types of platelets?

Answer 1

Apheresis - single donor
Pooled - whole blood derived (4 donations)

Question 2

What are the risks of platelet transfusions?

Answer 2

Allo-immunisation
Transmission of infection
Allergic reactions
Transfusion-related acute lung injury

Question 3

What are the benefits of platelet transfusions?

Answer 3

Reduced morbidity associated with minor haemorrhage
Reducing morbidity/mortality resulting from major bleeding

Question 4

At what temperature are platelets stored and why can this be a problem?

Answer 4

Stored at room temperature between 20-24 degrees. Too cold temperatures can lead to damage to the platelet membranes. These warmer temperatures are much more favourable for bacterial contamination and growth, compared to products stored at colder temperatures.

Question 5

What are some indications for a platelet transfusion?

Answer 5

Active bleeding with associated thrombocytopenia
Prophylaxis for reversible bone marrow failure, include allogenic stem cell transplant and critical illness
Prophylaxis for chronic bone marrow failure if patient is receiving intensive treatment eg. chemotherapy

Question 6

What are some contraindications of a platelet transfusion?

Answer 6

Autoimmune ITP
Thrombotic ITP (could cause micro thrombi)