Pneumothorax Case Drugs Flashcards
(2 cards)
Anaesthetic effect table
General anaesthesia mechanism
it can be hypothesized that anaesthesia results from either enhanced inhibitory transmission or reduced excitatory transmission. Two main targets include; GABAA receptors and N-methyl-D-aspartate (NMDA) glutamate receptors. On γ-aminobutyric acid (GABA) binding to GABAA receptors an influx of Cl− ions results to produce a hyperpolarization. With the exception of ketamine, xenon and nitrous oxide, all anaesthetic agents potentiate (increase the power of) the inhibitory function of GABA-mediated conductance. On binding of the main excitatory transmitter glutamate, NMDA receptors gate an influx of Ca2+ and Na+. Ketamine, xenon and nitrous oxide inhibit this ion movement to depress excitatory transmission.
