Podcast reviews

Question 1

Brain Capillaries have what kind of polarity?

Answer 1

Endothelial:

Basal and Apical

Question 2

Route of transport in brain

Answer 2

tight junctions: keeps cellular route intracellular

Question 3

Three components to BBB

Answer 3

basal lamina
pericytes
astrocyte foot processes

Question 4

cover abluminal surface (surface that faces away from capillary lumen or towards the brain)

Answer 4

astrocyte foot processes

Question 5

Cells that have sm. muscle properties

Answer 5

pericytes

Question 6

Tight junctions limits mvmt of what type of agents

Answer 6

Tight jnx limit movment of water soluble agents

Question 7

What pathway allows O2, CO2 and drugs and other lipophilic molecules?

Answer 7

Transcellular

Question 8

Receptor mediated transcytosis use __________ and ________

Answer 8

insulin and transferrin

Question 9

What is the process of transcytosis?

Answer 9

Plasma proteins (albumin) get surrounded by Cations

Question 10

Can glucose move against the conc gradient?

Answer 10

No: its is non-E dependent

Question 11

What is the metabolic barrier in the brain?

Answer 11

Enz system specific to BBB regulate composistion of brain interstial fluid

Question 12

Astrocyte foot processes surround which surface?

Answer 12

Albuminal

Question 13

What are the 3 functions of astrocytes?

Answer 13

1. Regulate tight jnx (physical)
2. Influence expression and polarization of transporters (transporter)
3. Influence expression of enZ systems (metabolic)

Question 14

How can you disrupt the BBB?

Answer 14

Down regulate proteins in tight jnx, break down basil lamina, influence secretion of proteins

Question 15

What pathology is the BBB absent from?

Answer 15

brain tumors–thus amendable to chemotherapy

Question 16

Methods to disrupt BBB

Answer 16

Stroke/trauma/infection/MS/HIV/Alzeihmers disease/Parkinsons/Epilepsy/Tumor/Pain

Question 17

What organs lack a BBB

Answer 17

Circumventricular organs

Question 18

Sensory receptors here require access to blood to monitor blood so it can send signal to ant. Pit for homeostasis purpose

Answer 18

Median eminense

Question 19

6 Circumventricular Organs

Answer 19

area postrima
pineal gland
Choroid plexus of third ventricle
Subfornical organ
vascular organ of lamina terminalis
Median Eminense

Question 20

BBB have less/more pinocytotic vesicles

Answer 20

less

Question 21

BBB has ________ and capilary has _________

Answer 21

tight…. gap

Question 22

Veins of the Cerebrum have valves/no valves and are in how many groups?

Answer 22

No valves, 2 groups

Question 23

What drains superolateral and medial surfaces of cerebral hemis?

Answer 23

Superficial Superior Vein

Question 24

Where does the superficial superior vein empty into?

Answer 24

Superior Sagittal Sinus

Question 25

What veins join the superior sagittal sinus at right angles?

Answer 25

Anterior superficials

Question 26

What is the direction of blood flow?

Answer 26

angles are significant; blood flow it anterior→posterior

Question 27

What keeps posterior veins from collapsing?

Answer 27

pressure keeps posterior veins from collapsing

Question 28

Where is the superficial middle vein located?

Answer 28

In the Sylvian fissure

Question 29

What does the superficial middle vein drain?

Answer 29

Lateral surface of cerebral hemisphere

Question 30

Where does the superficial middle vein empty into?

Answer 30

Cavernous sinus

Question 31

Where is the Superficial inferior vein located?

Answer 31

on Orbital surface of Frontal lobe + Inferior surface of temporal lobe

Question 32

What two veins does the Superficial inferior vein turn into?

Answer 32

Orbital vv | Temporal vv

Question 33

Orbital vv empties to :

Answer 33

Superior Sagittal Sinus

Question 34

Temporal vv empties into:

Answer 34

Cavernous sinus (via middle cerebral veins)

Question 35

Superior Anastomotic Veins connects what to what?

Answer 35

-Connect Superficial Middle Cerebral w/ Superior Sagittal Sinus Called veins of Trolard

Question 36

Inferior Anastomotic Veins (of Labbe) connects:

Answer 36

Connect Superficial Middle to Transverse sinus

Question 37

Inferior Anastomotic Veins (of Labbe) runs over

Answer 37

runs over temporal lobe

Question 38

Basal vein is made up of what two veins?

Answer 38

Anterior cerebral vein (drains medial aspect of cerebral hemis) + deep middle cerebral vein (drains insula and surrounding gyri) -drains medial aspect of cerebral hemis