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Virology Test 2 > poxviridae 1 > Flashcards

poxviridae 1 Flashcards

1
Q

Poxviridae is

A

family

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2
Q

Chordopoxvirinae

A

subfamily

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3
Q

genus groups of Poxviridae

A

orthopoxvirus
parapoxvirus
avipoxvirus

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4
Q

poxvirus general characteristics

A

DNA, complex symmetry

pleomorphic, usually brick-shaped (orthopoxvirus) or ovoid shaped (parapoxvirus), large, sometimes enveloped

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5
Q

names of infectious forms of Poxvirus

A

IMV=intracellular mature virus

EEV=extracellular enveloped virions

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6
Q

EEV has

A

2 membranes
envelope and inner membrane
extra envelope a consequence of budding

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7
Q

IMV

A

only an inner membrane, only by disruption of cell to release virus

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8
Q

complex symmetry

A

outer layer covers dumbbell shaped core with viral DNA, two lateral bodies keep the core in place

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9
Q

genome

A

single molecule of linear double stranded DNA, cross links join two DNA strands at both ends, many protein are involved in nucleic acid synthesis and vision structural components and also those that counteract host proteins

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10
Q

replication

A

located in cytoplasm, because has own polymerase, virions are released by budding, cell lysis (most common), or exocytosis
-enveloped versions are more important for spread of virus

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11
Q

special about pox envelopes in EEV

A

low lipid content-> allows more stability in environment

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12
Q

transmission of pox

A

skin- open wounds
respiratory- aerosol inhalation
mechanically- arthropod

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13
Q

pathogenesis of immunity

A

highly epitheliotropic (infect epithelium readily)

  • can cause systemic disease in wild birds and animals
  • most pox viruses are host specific, yet orthopoxviruses
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14
Q

spread of pox

A

will get into the body then gains access to the systemic circulation and to other target organs through secondary viremia

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15
Q

pox virus can survive in scabs or other forms including

A

macule-local inflammation flat red
papule-raised red inflammation invading neighboring tissue
vesicle-microbe invades epithelium, small blister
ulcer-epithelium ruptures, microbes discharged

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16
Q

pox genus: orthopoxvirus

distribution (cowpox)

A

Europe and Asia

17
Q

orthopox hosts (cowpox)

A

cattle, wild and domestic cats, humans, zoo animals

rodents are reservoir

18
Q

orthopox: cow pox transmission

A

milkers hand or teat cups
infected farm cats also transmit the disease
rodents are reservoir

19
Q

cow pox economic importance

A

lose milk, due to soreness and inconvenience

20
Q

cow pox clinical findings

A

incubation 3-7 days, papules on teats, vesicles erupt rapidly

21
Q

cow pox transmission in cats

A

inoculation through open wounds or scratches or rodent bites
oro-nasal rote possible

22
Q

clinical signs cow pox in cats

A

single primary skin lesion on head neck or forelimb that can form a small scab or abscess
secondary- 7-10 day incubation papules to ulcers to scabs

23
Q

cowpox in humans transmission

A

direct contact with cuddly cats

very are from cattle

24
Q

cowpox in humans clinical signs

A

hand and face macropapular lesions, enlarged painful local lymph nodes, may report fever vomitting and sore throat

25
Q

other orthopoxvirus include

A

Variola (smallpox humans), Camelpox, Ectromelia, Horsepox, Rabbitpox, Vaccinia, Uasin Gishu Disease

26
Q

ortho- monkey pox

A

humans is similar to smallpox

in monkeys- generalized skin eruption papules on face truck palms and sole

27
Q

monkey transmission in humans

A

primary-direct contact with blood or body fluids through Gambian rats or squirrels
secondary-close contact with respiratory excretions

28
Q

monkey pox clinical signs humans

A

invasion (0-5 days)- fever, intense headache, lymphadenopathy, muscle pain
skin eruption- evolution of the rash maculo-papules with flat bases, to vesicles, pustules, ulcers

Virology Test 2 (7 decks)

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