PPT 14: Cardiac Arrhythmias Flashcards

Exam 2 (55 cards)

1
Q

How prevalent are cardiac arrhythmias in anesthetized patients?

A

50%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the types of cardiac arrhythmias?

A
  1. Bradycardia - Slowing (<60 bpm)
  2. Block
  3. Tachycardia
    - Supraventricular (SVT, atrial)
    - Sinus (regular)
    - Ventricular Tachycardia (Vtach)
  4. Fibrillation (Atrial or Ventricular)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the components of the intrinsic conduction system of the heart?

A

Sinoatrial node/pacemaker
Atrioventricular node
Atrioventricular bundle/bundle of His
Purkinje fibers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Which part of the intrinsic conduction system is the pacemaker of the heart? What is the contraction rate?

A

SA node - 75 beats/min

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

The _______ is the crescent shaped node in right atrium of the intrinsic conduction system

A

Sinoatrial node/pacemaker

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

The _______ is the junction of atria and ventricles of the intrinsic conduction system

A

Atrioventricular node

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How fast does the AV node contract?

A

40-50 beats/min - slow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

The _______ is in the interventricular septum of the intrinsic conduction system

A

Atrioventricular bundle/bundle of His

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

The _______ is spread within the muscle of the ventricle walls of the intrinsic conduction system

A

Purkinje fibers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Discuss the changes of the electrocardiogram throughout the intrinsic conduction system

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Impulses that deviate from the normal electrical pathway are _______

A

Arrhythmias

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the different types of abnormalities of arrhythmias?

A
  • Site of origin
  • Rate
  • Regularity
  • Conduction
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are the 3 main ions that determine cardiac action potential?

A
  • Sodium
  • Potassium
  • Calcium
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Discuss the phases of ion channel currents in cardiac action potential

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Discuss the three states of sodium channels

A
  1. Resting
    - slowly approaching threshold
    - m gates closed
  2. Activated
    - threshold reached; m gates open
    - massive sodium influx
  3. Inactivated - h gates close
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

The ________ is the time between the inactivation and resting states of sodium channels

A

Refractory period

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

K+ channels are open at rest are called ______

A

Inward rectifier channels - Very little flow (electrical gradient)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

______ establish the membrane potential of resting cardiac cell

A

K+ current

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Ca++ channels open _____ and at more ______ potentials

A

slowly and positive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What are the 2 main classes of arrhythmias?

A
  1. Disturbances in Impulse Formation
  2. Disturbances in Impulse Conduction
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What are the types of disturbances in impulse formation that result in arrhythmias?

A
  • Early or late afterdepolarizations
  • SA/AV nodal abnormalities
  • Ion changes
  • SNS stimulation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What are the types of disturbances in impulse conduction that result in arrhythmias?

A
  • Block
  • Reentry
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Abnormal depolarizations that occur during phase 2, 3, or 4

A

Afterdepolarizations (AD)

24
Q

Differentiate between Early (EAD) and Delayed Afterdepolarizations (DAD)

A

Early Afterdepolarizations (EAD)
- Phase 2 or 3
- Sodium or calcium channels

Delayed Afterpolarizations (DAD)
- Occur before a normal action potential
- Elevated intercellular calcium

25
Severe depression of conduction may result in ______
block
26
Discuss the ECG changes of the various degrees of heart block
27
________ inhibits conduction of depolarization
Heart block
28
What is considered "blocked" in heart block?
- AV nodal block - Bundle branch block - Block – allows one-way conduction
29
Describe the reentry block and "circus movement"
One impulse “circles around” and re-excites areas more than once
30
What must happen in order for reentry to occur?
- There must be an obstacle (scar tissue) - Block must be unidirectional - Conduction time must be long enough to reenter same areas *after* refractory period
31
How is heart block treated?
- Type II/III: Transcutaneous pacing, pacemaker - Pharmacology (reentry): a. Slow down circular current – sync with next action potential - Drugs – block sodium or calcium current b. Lengthen or shorten refractory period
32
What are the 4 classes of antiarrhythmic agents?
Vaughan-Williams classification: - Class I – sodium channel blockade - Class II – sympatholytic (beta blockers) - Class III – prolong action potential duration (other mechanisms besides sodium channels – K+) - Class IV – block cardiac calcium channel currents
33
What are the 3 subclasses of Class I antiarrhythmic agents?
IA, IB, IC
34
What meds are included in Class IA antiarrhythmic agents? What are the effects on APD and ERP? What are the cardiac effects?
Quinidine (Procainimide, Disopyramide) - Prolong the action potential duration (APD) - ↑ Effective Refractory Period (ERP) - Cardiac effects: Depresses pacemaker rate, Lengthens QT interval, Depresses conduction and excitability
35
What meds are included in Class IB antiarrhythmic agents? What are the effects on APD and ERP?
Lidocaine - Shorten the APD - ↓ ERP
36
What meds are included in Class IC antiarrhythmic agents? What are the effects on APD and ERP?
Flecainide - Minimal effects on APD - Slow dissociation - No effect on ERP (But Na+ channels are still blocked)
37
What meds are included in Class II antiarrhythmic agents? How do these agents work as antiarrhythmics?
Beta blockers - propanolol and esmolol (short acting) - Antiarrhythmic properties associated with direct membrane effects - Exact antiarrhythmic action unknown - Suppress ventricular ectopic depolarization - Prevent infarction and sudden death in patients recovering from acute MI
38
What meds are included in Class III antiarrhythmic agents? How do these agents work as antiarrhythmics?
Amiodarone (VT) and dronedarone (A-fib) Prolong AP usually by: - Blocking cardiac K+ channels - Enhancing inward current (Na+ or Ca2+ channels)
39
What meds are included in Class IV antiarrhythmic agents? How do these agents work as antiarrhythmics?
Calcium channel blockers - verapamil - Prolongs AV node conduction - Slows SA node - Hypotensive action - Useful for supraventricular arrhythmias - Can reduce ventricular rate in atrial fibrillation and flutter
40
What are the antiarrhythmic agents that do not fit into the conventional classes?
- Digoxin - Adenosine - SVT, Enhanced K+ conductance, Inhibition of cAMP induced calcium influx - Magnesium - digitalis induced arrhythmias - Potassium - normalizing levels
41
What are the non-pharmacologic interventions used to treat arrhythmias?
- Vagal maneuvers - Pacemakers - Cardioversion - Catheter ablation - Surgery
42
What is the treatment for symptomatic bradycardia?
1st - atropine 2nd - epi, dopamine
43
What is the treatment for chronic bradycardia?
pacemaker
44
What is the treatment for symptomatic heart block?
atropine and transcutaneous pacing
45
What is the treatment for chronic heart block?
pacemaker
46
What is the treatment for symptomatic SVT?
adenosine
47
What is the treatment for chronic SVT?
CCBs, beta blockers
48
What is the treatment for symptomatic sinus tachycardia?
Adenosine, CCBs, cardioversion
49
What is the treatment for chronic sinus tachycardia?
catheter ablation
50
What is the treatment for symptomatic Vtach?
amiodarone
51
What is the treatment for chronic Vtach?
amiodarone, satolol
52
What is the treatment for symptomatic Afib?
diltiazem, verapamil
53
What is the treatment for chronic Afib?
beta-blockers, amiodarone
54
What is the treatment for symptomatic Vfib?
CPR, defirillation
55
What is the treatment for chronic Vfib?
amiodarone, lidocaine