Practice Exam Questions Flashcards
Which of the following databases is best used to readily identify mutations that occur in individual,cancer-related genes?
a. COSMIC
b. genome.ucs
c. educ.OMIM
d. pubmed.com
Which of the following terms means a representation of a metaphase chromosome?
a. CpG island
b. fluorescence
c. ideogram
d. primary transcript
Which of the following is important for mis-match repair?
a. MSH6
b. MutL
c. both
d. neither
Massively parallel DNA sequencing includes a process of accumulating many sequences representing small stretches of the genome followed by a computer-mediated process of determining __________.
a. accidental intron duplications
b. gene homologies
c. DNA sequence overlap
d. the positions of middle repetitive sequences
Which of the following is important to drive nucleic acid synthesis forward?
a. hydrolyze pyrophosphate
b. prevent helicase activity
c. inducetorsional stress
d. reform double stranded template
The advent of massively parallel DNA sequencing technologies has stimulated rapid cataloging of all alterations in __________genomes.
A. achondroplasia
B. cancer
C. osteogenesis imperfecta
D. phenylketonuria
Which of the following processes has been important in the evolutionary development of super gene families?
A. accidental methylation
B. chromosome degradation
C. deamination of nitrogenous bases
D. exon shuffling
Which of the following is the best way to order DNA replication enzyme activities?
A. Helicase 🡪 Ligase 🡪 Primase
B. RNAse H 🡪 Primase 🡪 Topoisomerase
C. Helicase 🡪 Primase 🡪 DNA polymerase δ (delta)
D. DNA polymerase ε (epsilon) 🡪 Helicase 🡪 PCNA
Bloom syndrome is due to a defect in a DNA______________.
A. helicase
B. ligase
C. luciferase
D. primase
If the above figure were to represent a natural substrate for DNA polymerase, which ribose position would need to have a hydroxyl group?
1’
2’
3’
4’
