Pralidoxime

Question 1

Pralidoxime Trade Name?

Answer 1

Protopam, 2PAM

Question 2

Pralidoxime Classification?

Answer 2

Cholinergic, Toxicity Antidotes

Question 3

Pralidoxime Mechanism?

Answer 3

Binds to organophosphates and breaks alkyl phosphate-cholinesterase bond to restore the activity of acetylcholinesterase. Primarily works at the nicotinic receptors

Question 4

Pralidoxime Indications?

Answer 4

Suspected organophosphate poisoining

Question 5

Pralidoxime Contraindications?

Answer 5

None in emergency setting

Question 6

Pralidoxime Side Effects/Precautions?

Answer 6

Pain at injection site, blurred vision, diplopia, HTN, tachycardia, cardiac arrest, laryngospasm, muscle rigidity, headache, Sz, drowsiness, nausea

Question 7

Pralidoxime Adult Dose?

Answer 7

600mg IM x 3 doses q 15 min; if symptoms persist, 1g IV/IO x 60 min

Question 8

Pralidoxime Pediatric Dose?

Answer 8

< 40kg: 15mg/kg/dose IM x 3 dose q 15 min.
> 40kg: 600mg IM x 3 doses q 15 min
25 mg/kg IV/IO/IM (max 2 grams), rep. PRN within 30-60 min.

Question 9

Pralidoxime Onset of Action?

Answer 9

5-15 minutes

Question 10

Pralidoxime Duration of Action?

Answer 10

2 hours

Question 11

Pralidoxime Max Dose Adult/Pediatric?

Answer 11

Adults and peds over 40kg: 1800mg. Peds <40kg: 45mg/kg

Question 12

Pralidoxime Routes of Administration?

Answer 12

IV/IO/IM

Question 13

Pralidoxime How Supplied?

Answer 13

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