Pregnancy Flashcards
(20 cards)
Molar pregnancy is a _ disease of pregnancy
Molar pregnancy is a trophoblastic disease of pregnancy
* Placental tissue goes rogue
_ are the trophoblastic cells that make beta-hCG
Syncytiotrophoblast are the trophoblastic cells that make beta-hCG
_ are the trophoblastic cells that make villi in the uterus
Cytotrophoblasts are the trophoblastic cells that make villi in the uterus
A complete mole occurs when a _ ovum joins with _ sperm
A complete mole occurs when an enucleated ovum joins with 1 sperm –> paternal DNA gets duplicated
The karyotype of a complete mole will be _ or _
The karyotype of a complete mole will be 46XX or 46XY
* The most common form is 46XX
Complete moles are associated with _ B-hCG levels
Complete moles are associated with very high B-hCG levels
A partial mole occurs when a _ ovum joins _ sperm
A partial mole occurs when a normal ovum joins 2 sperm
(Complete/Partial) moles are associated with higher B-hCG levels
Complete moles are associated with higher B-hCG levels
(Complete/Partial) moles are associated with more hydropic villi (chorionic villi)
Complete moles are associated with more hydropic villi (chorionic villi)
Partial moles will have one of the following karyotypes:
Partial moles will have one of the following karyotypes: 69XXX, 69XXY, 69XYY
_ mole will cause mild increase in B-hCG and minimal hydropic villi and proliferation
Partial mole will cause mild increase in B-hCG and minimal hydropic villi and proliferation
(Complete/Partial) moles have a greater risk of choriocarcinoma
Complete moles have a greater risk of choriocarcinoma
(Complete/Partial) mole involves placental tissue taking up the entire uterine cavity leading to an enlarged uterus
Complete mole involves placental tissue taking up the entire uterine cavity leading to an enlarged uterus
A (complete/partial) mole will result in a normal size uterus but may present with fetal parts
A partial mole will result in a normal size uterus but may present with fetal parts
Moles will classically present with the following symptoms:
Moles will classically present with the following symptoms:
* Morning sickness
* Pelvic discomfort
* First semester vaginal bleeding
* Increased uterine fundus size for gestational age
* Grape-like mass
* High B-hCG > 100
Molar pregnancy may result in _ first semester vaginal bleeding
Molar pregnancy may result in prune juice first semester vaginal bleeding
How will a mole present on ultrasound?
Central heterogeneous mass with multiple discrete anechoic spaces
* Complete mole: snowstorm, grape cluster, honeycomb
_ is malignancy of trophoblastic tissue in the mother or baby during or after pregnancy
Choriocarcinoma is malignancy of trophoblastic tissue in the mother or baby during or after pregnancy
* Increase B-hCG, no chorionic villi, +/- bilateral theca lutein cysts
Choriocarcinoma is associated with _ metastasis to the _ (most commonly)
Choriocarcinoma is associated with cannonball metastasis to the lungs (most commonly)
* Hematogenous spread to the lungs
* Presents with SOB and hemoptysis
We treat choriocarcinoma with _
We treat choriocarcinoma with methotrexate
* Very treatable
