PRELIM - ENZYMES-L1

Question 1

INHIBITORS:
- Physically bind to the ACTIVE Site of an enzyme and COMPETE WITH THE SUBSTRATE FOR THE ACTIVE SITE

Answer 1

COMPETITIVE INHIBITION

Question 2

INHIBITORS:
- Binds an enzyme at a place OTHER THAN THE ACTIVE SITE AND MAY BE REVERSIBLE IN THAT SOME NATURALLY PRESENT METABOLIC SUBSTANCES COMBINE REVERSIBLY WITH CERTAIN ENZYMES.

Answer 2

NON COMPETITIVE INHIBITION

Question 3

TRUE OR FALSE
- NON COMPETITIVE INHIBITORS may also be IRREVERSIBLE if the INHIBITOR destroys part of the enzyme involved in catalytic activity.

Answer 3

TRUE

Question 4

INHIBITOR:
- This inhibitor binds to the ES complex—increasing substrate concentration results in more ES complexes to which the inhibitor binds and, thereby, increases the inhibition.

Answer 4

UNCOMPETITIVE INHIBITION

Question 5

CLINICAL SIGNIFICANCE:
PROSTATIC CARCINOMA

Answer 5

ACID PHOSPHATASE

Question 6

CLINICAL SIGNIFICANCE:
PROSTATIC CARCINOMA

Answer 6

ACID PHOSPHATSE

Question 7

CLINICAL SIGNIFICANCE:
HEPATIC DISORDER

Answer 7

ALANINE AMINOTRANSFERASE

Question 8

CLINICAL SIGNIFICANCE of ALANINE AMINOTRANSFERASE

Answer 8

HEPATIC DISORDER

Question 9

What is the CLINICAL SIGNIFICANCE OF ALKALINE PHOSPHATASE?

Answer 9

HEPATIC DISORDER
BONE DISORDER

Question 10

CLINICAL SIGNIFICANCE:
HEPATIC DISORDER & BONE DISORDER
What enzyme?

Answer 10

ALKALINE PHOSPHATASE

Question 11

CLINICAL SIGNIFICANCE OF AMYLASE?

Answer 11

ACUTE PANCREATITIS

Question 12

CLINICAL SIGNIFICANCE: ACUTE PANCREATITIS

Answer 12

AMYLASE

Question 13

CLINICAL SIGNIFICANCE OF Angiotensin-converting enzyme (ACE)

Answer 13

BLOOD PRESSURE REGULATION

Question 14

CLINICAL SIGNIFICANCE: Blood pressure regulation

Answer 14

ACE

Question 15

What is the CLINICAL SIGNIFICANCE OF AST?

Answer 15

MYOCARDIAL INFARCTION
HEPATIC DISORDER
SKELETAL MUSCLE DISORDER

Question 16

CLINICAL SIGNIFICANCE:
MYOCARDIAL INFARCTION
HEPATIC DISORDER
SKELETAL MUSCLE DISORDER

Answer 16

ASPARTATE AMINOTRANSFERASE

Question 17

CLINICAL SIGNIFICANCE of CREATINE KINASE?

Answer 17

MYOCARDIAL INFARCTION
SKELETAL MUSCLE DISORDER

Question 18

CLINICAL SIGNIFICANCE:
MYOCARDIAL INFARCTION
SKELETAL MUSCLE DISORDER
- What enzyme?

Answer 18

CREATINE KINASE

Question 19

What is the CLINICAL SIGNIFICANCE of G-6-PD?

Answer 19

DRUG-INDUCED HEMOLYTIC ANEMIA

Question 20

CLINICAL SIGNIFICANCE: DRUG-INDUCED HEMOLYTIC ANEMIA
- What enzyme?

Answer 20

GLUCOSE-6-PHOSPHATE DEHYDROGENASE

Question 21

What is the CLINICAL SIGNIFICANCE OF GGT?

Answer 21

HEPATIC DISORDER

Question 22

CLINICAL SIGNIFICANCE: HEPATIC DISORDER
- What enzyme?

Answer 22

GAMMA-GLUTAMYLTRANSFERASE

Question 23

What is the CLINICAL SIGNIFICANCE OF LACTATE DEHYDROGENASE?

Answer 23

MYOCARDIAL INFARCTION
HEPATIC DISORDER
HEMOLYSIS
CARCINOMA

Question 25

CLINICAL SIGNIFICANCE: MYOCARDIAL INFARCTION HEPATIC DISORDER HEMOLYSIS CARCINOMA - What enzyme?

Answer 25

LACTATE DEHYDROGENASE

Question 26

What is the CLINICAL SIGNIFICANCE OF LIPASE?

Answer 26

ACUTE PANCREATITIS

Question 28

What is the CLINICAL SIGNIFICANCE OF 5'-NUCLEOTIDASE?

Answer 28

HEPATIC DISORDER

Question 29

CLINICAL SIGNIFICANCE: HEPATIC DISORDER - What enzyme?

Answer 29

GGT

Question 30

What is the CLINICAL SIGNIFICANCE of PSEUDOCHOLINESTERASE?

Answer 30

ORGANOPHOSPHATE POISONING GENETIC VARIANTS HEPATIC DISORDER SUXAMETHONIUM SENSITIVITY

Question 31

CLINICAL SIGNIFICANCE: ORGANOPHOSPHATE POISONING GENETIC VARIANTS HEPATIC DISORDER SUXAMETHONIUM SENSITIVITY - What enzyme?

Answer 31

PSEUDOCHOLINESTERASE (PChE)

Question 32

ISOENZYME: CK MM what are the CONDITIONS ASSOCIATED?

Answer 32

MYOCARDIAL INFARCTION SKELETAL MUSCLE DISORDER POLYMYOSITIS HYPOTHYROIDISM MALIGNANT HYPERTHERMIA PHYSICAL ACTIVITY INTRAMUSCULAR INJECTION

Question 34

ISOENZYME: CK-MB what are the CONDITIONS ASSOCIATED?

Answer 34

MYOCARDIAL INFARCTION MYOCARDIAL INJURY ISCHEMIA ANGINA INFLAMMATORY HEART DISEASE CARDIAC SURGERY DUCHENNE-TYPE MUSCULAR DYSTROPHY POLYMYOSITIS MALIGNANT HYPERTHERMIA REYE'S SYNDROME ROCKY MOUNTAIN SPOTTED CARBON MONOXIDE POISONING

Question 35

ISOENZYME: CK-BB what are the CONDITIONS ASSOCIATED?

Answer 35

CENTRAL NERVOUS SYSTEM SHOCK ANOXIC ENCEPHALOPATHY CEREBROVASCULAR ACCIDENT SEIZURE PLACENTAL OR UTERINE TRAUMA CARCINOMA REYE'S SYNDROME CARBON MONOXIDE POISONING MALIGNANT HYPERTHERMIA ACUTE AND CHRONIC RENAL FAILURE

Question 36

TISSUE SOURCES OF CK-BB?

Answer 36

BRAIN BLADDER LUNG PROSTATE UTERUS COLON STOMACH THYROID

Question 37

What are the TISSUE SOURCES OF CK-MB?

Answer 37

HEART SKELETAL MUSCLE

Question 38

WHAT ARE THE TISSUE SOURCES OF CK-MB

Answer 38

HEART & SKELETAL MUSCLE

Question 39

TISSUE SOURCES OF CK-MM?

Answer 39

HEART & SKELETAL MUSCLE

Question 40

Major isoenzyme fraction found in striated muscle and normal serum.

Answer 40

CK-MM

Question 41

3 ISOENZYME: CK-BB

Answer 41

BRAIN TYPE

Question 43

3 ISOENZYME: CK-MB

Answer 43

HYBRID TYPE

Question 44

3 ISOENZYME: CK-MM

Answer 44

MUSCLE TYPE

Question 45

ISOENZYME that migrate fastest toward the ANODE

Answer 45

CK-BB (CK1)

Question 46

The major isoenzyme in the sera of HEALTHY PEOPLE is?

Answer 46

CK-MM

Question 47

ISOENZYME OF CK from CATHODAL-ANODAL

Answer 47

MI>MM>MACRO>MB>BB

Question 48

CK-BB short half-life:

Answer 48

1-5 hours

Question 49

REFERENCE RANGE OF CK: MALES: FEMALES:

Answer 49

(This is from BISHOP) Males: 46 to 171 U/L (37°C) (0.8 to 2.9 µkat/L) Females: 34 to 145 U/L (37°C) (0.6 to 2.4 µkat/L) CK-MB: <5% total CK