(Prelim) Introduction

Question 1

Investigation of physical and chemical properties of drug molecules.

Answer 1

Pharmaceutics

Question 2

Design, fabrication, and evaluation of Drug Delivery Systems

Answer 2

Pharmaceutics

Question 3

Monitoring of how the drug is absorbed, distributed, metabolized, and excreted in the body

Answer 3

Pharmaceutics

Question 4

INVESTIGATION OF PHYSICAL AND CHEMICAL PROPERTIES OF DRUG MOLECULES.

Answer 4

PHYSICAL PHARMACY

Question 5

Physical form

Answer 5

Physical Properties

Question 6

Particle size

Answer 6

Physical Properties

Question 7

Melting point

Answer 7

Physical Properties

Question 8

Solubility & Dissolution

Answer 8

Physical Properties

Question 9

Partition Coefficient

Answer 9

Physical Properties

Question 10

Refractive index

Answer 10

Physical Properties

Question 11

Specific Gravity

Answer 11

Physical Properties

Question 12

Chemical structures

Answer 12

Chemical Properties

Question 13

Optical Activity

Answer 13

Chemical Properties

Question 14

Polymorphism

Answer 14

Chemical Properties

Question 15

Ionization

Answer 15

Chemical Properties

Question 16

Complexation and Protein
binding

Answer 16

Chemical Properties

Question 17

most often a formulation of the drug with various excipients

Answer 17

dosage form

Question 18

administered to a patient as a specific drug product which is a particular dosage form.

Answer 18

drug

Question 19

can be formulated in a variety of dosage forms and can be administered in different routes of administration

Answer 19

Drug products

Question 20

Drugs that are administered in a certain route should be __________ in order for them to become bioavailable to the systemic circulation.

Answer 20

absorbed

Question 21

Monitoring of how the drug is absorbed, distributed, metabolized, and excreted in the body.

Answer 21

PHARMACOKINETICS

Question 22

8 mg/L

Answer 22

peak concentration

Question 23

1.5 hours

Answer 23

time of peak

Question 24

ADBE

Answer 24

Absorption, Distribution, Biotransformation, Excretion

Question 25

Study of the physicochemical properties of drugs and their proper dosage form as related to the onset, duration, and intensity of drug action

Answer 25

BIOPHARMACEUTICS

Question 26

2 types of solid in Physical Form

Answer 26

Crystalline Solid Amorphous Solid

Question 27

most common solid

Answer 27

Crystalline Solid

Question 28

distinct melting point

Answer 28

Crystalline Solid

Question 29

boiling point 190°C-192°C

Answer 29

Crystalline Solid

Question 30

wider melting point

Answer 30

Amorphous Solid

Question 31

not repeated arrangement of atoms

Answer 31

Amorphous Solid

Question 32

different melting point

Answer 32

Amorphous Solid

Question 33

180°C - 190°C

Answer 33

Amorphous Solid

Question 34

affect the stability & pharmacokinetics drugs

Answer 34

particle size

Question 35

polar & non-polar

Answer 35

Solubility & Dissolution

Question 36

- equilibrium - forces of attraction: higher - 190°C- 192°C

Answer 36

Melting Point

Question 37

determine substance purity

Answer 37

Melting Point

Question 38

measure of drug concentration in nonpolar organic phase relative to the polar aqueous phase

Answer 38

Partition Coefficient

Question 39

hates water and loves lipids

Answer 39

Hydrophobicity (or lipophilicity)

Question 40

- hates water - lipid-loving

Answer 40

hydrophobic

Question 41

non-polar

Answer 41

lipids

Question 42

ability of substance to rotate plane polarized light.

Answer 42

Optical Activity

Question 42

measure of how much the speed of light bends or reduced inside a medium

Answer 42

Refractive Index

Question 43

include peripheral neuropathy, constipation, fatigue, and sedation.

Answer 43

Thalidomide toxicity

Question 43

If a compound rotates plane polarized light in the clockwise (+) direction, it is said to be ____________

Answer 43

dextrorotatory

Question 44

the presence of two or more variant forms of a specific DNA sequence that can occur among different individuals or populations.

Answer 44

Polymorphism

Question 45

if it rotates light in the counterclockwise (-) direction it is ____________

Answer 45

levorotatory

Question 46

failure to calibrate

Answer 46

Instrumentation Errors

Question 46

may be defined as a deviation from the absolute value or from the true average of a large number of results

Answer 46

Errors

Question 47

affects absorption

Answer 47

pH and Ionization

Question 48

3 TYPES OF DETERMINATE ERROR

Answer 48

* Instrumentation Errors * Method Errors * Personal Errors

Question 48

degredation of parts

Answer 48

Instrumentation Errors

Question 49

TYPE OF ERRORS

Answer 49

* Determinate Errors * Indeterminate Errors * Pseudo-accidental or Variable Determinate Errors

Question 50

errors due to non-ideal physical or chemical behavior

Answer 50

Method Errors

Question 50

power fluctuation

Answer 50

Instrumentation Errors

Question 51

flaws introduced by the observer

Answer 51

Personal Errors

Question 52

errors that can be measured

Answer 52

DETERMINATE ERROR

Question 53

usually detectable and can be corrected

Answer 53

DETERMINATE ERROR

Question 54

arises from the design of experiment

Answer 54

DETERMINATE ERROR

Question 55

error by chance/ accidental in nature

Answer 55

INDETERMINATE ERROR

Question 56

limitations of reading balances, scales such as rulers or dials, and electrical “noise” in instruments.

Answer 56

INDETERMINATE ERROR

Question 57

They arise from random fluctuation in temperature or other external factors, changes in pH

Answer 57

PSEUDO-ACCIDENTAL/ VARIABLE DETERMINATE

Question 57

environmental factors

Answer 57

PSEUDO-ACCIDENTAL/ VARIABLE DETERMINATE

Question 58

same production

Answer 58

Repeatability

Question 58

reproducibility and repeatability

Answer 58

PRECISION AND ACCURACY

Question 59

2 Types of Precision

Answer 59

* Repeatability * Reproducibility

Question 60

the precision when a single analyst completes the analysis in a single session using the same solutions, equipment, and instrumentation.

Answer 60

Repeatability

Question 61

the precision under any other set of conditions, including between analysts, or between laboratory sessions for a single analyst.

Answer 61

Reproducibility

Question 62

- different time - same day, different analyst

Answer 62

Reproducibility