(Prelims) BioPharm 1 Lec

Question 1

Study of Physicochemical properties of drugs and drug products

Answer 1

Biopharmaceutics

Question 2

In vivo

Outside/Inside?

Answer 2

Inside

Example: Gastric apparatus

Question 3

In vitro

Outside/nside?

Answer 3

Outside

Bioavailability of drug

Example: Dissolution tester, in which has 6 baskets wherein USP limit has 2/6 atleast should not dissolve. 4 must dissolve

Question 4

Drug = Active Ingredient
Drug Product = Formulation

True or False?

Answer 4

True

Question 4

What are the physical properties of drugs?

Answer 4

Shape/Form AKA Morphology
Color
Size

Question 5

What are the chemical properties of drugs?

Answer 5

Solubility/Miscibility
Concentration
L/W PC
pH

Question 6

What are the 2 layers of blood?

Answer 6

1. Serum Layer/Plasma
2. Aqueous Later

Question 7

Which is lipophilic?

Serum/Aqueous Layer?

Answer 7

Serum

Question 8

Which is hydrophilic?

Serum/Aqueous Layer?

Answer 8

Aqueous Layer

Question 9

Solvent-loving but not water

Answer 9

Lyophilic

Question 10

Where does the drug go?

Answer 10

Oil Layer

Question 11

Why does drug go to the oil layer?

Answer 11

Because drugs are mostly lipophilic

Question 11

Why should drug be Lipophilic?

Answer 11

Because our cell membrane is lipophilic, allowing the drug to penetrate to the phospholipid bilayer

Question 12

How to determine whether a drug is lipophilic based on structure?

Answer 12

More than 6 carbon atoms

Question 13

True or False:

The higher the MW, the lower the Lipophilicity

Answer 13

False

The higher the MW, the HIGHER the Lipophilicity

Question 14

True or False:

The higher the L/W PC, the lower the Lipophilicity

Answer 14

False

The higher the L/W PC, the HIGHER the Lipophilicity. OR MORE LIPOPHILIC

Question 15

If perfect product is not produced? We…

Answer 15

REFORMULATE

Question 16

What is the basic premise of biopharm?

Answer 16

ADJUSTING

Question 17

Why do we reformulate?

Answer 17

Achieve the best therapeutic activity

Question 18

Tends to absorb moisture from the air

Answer 18

Hygroscopic

Question 19

It is when drug is in the blood?

Answer 19

Systemic absorption

Question 20

It is when drug is in the arteries and veins

Answer 20

Systemic circulation

Question 21

Where most of the absorption happens

Answer 21

Duodenum

Question 22

Duodenum is made up of what?

Answer 22

Villi

Question 23

Yellow part of Villi?

Answer 23

Lacteal Absorb fats, oils, bypasses liver metabolism or the First Pass Effect

Question 24

Red Part of Villi?

Answer 24

Arteries

Question 25

Green part of Villi?

Answer 25

Veins

Question 26

Drug that does not need liver metabolism

Answer 26

Active drug When it goes to liver, it becomes inactive so when it goes to the systemic circulation it has no more effect.

Question 27

Drug that needs liver metabolism to become active

Answer 27

Prodrug

Question 28

Major protein of the blood

Answer 28

Albumin

Question 29

What happens when drug binds to albumin?

Answer 29

It does not render therapeutic effect or any adverse effects, and cannot go inside heart

Question 30

Drugs that does not bind to albumin?

Answer 30

Free drug

Question 31

When drug is in the heart and produces therapeutic effect

Answer 31

Tissue binding

Question 32

True or False: Protein bindings are reversible

Answer 32

True

Question 33

What is the use of the liver in this topic?

Answer 33

It converts lipophilic to hydrophilic, meaning when drug goes to kidney. It won't be eliminated but will provide adverse effect.

Question 34

Drug that only produces therapeutic effect when it goes to the heart, other than the heart it produces adverse effects, and if it goes to liver it becomes inactive

Answer 34

Active drug

Question 35

Drug that needs to go to liver, then if it goes to the kidney it will automatically be eliminated, but if it doesn't go straight to the kidney it will produce therapeutic/adverse effect

Answer 35

Prodrug

Question 36

True or False: All drugs go through the liver

Answer 36

True