Prescribing in Pregnancy

Question 1

Drugs to avoid in pregnancy

Answer 1

tetracyclines
aminoglycosides
sulphonamides and trimethoprim
quinolones

ACE inhibitors, angiotensin II receptor antagonists
statins
warfarin
sulfonylureas
retinoids (including topical)
cytotoxic agents

The majority of antiepileptics including valproate, carbamazepine and phenytoin are known to be potentially harmful

Question 2

What antiepileptic has the best safety profile in pregnancy?

Answer 2

Lamotrigine