Pressure Sore Flashcards

1
Q

A 34-year-old T12 paraplegic man presents with a Stage IV sacral pressure sore. The ulcer has been persistent and chronic, with exposed structures down to bone. Serial bedside debridements have maintained a clean and healthy-appearing wound. On admission, the patient has an increased erythrocyte sedimentation rate (ESR). Prior to definitive coverage, which of the following is the most appropriate next step in management?

A) Bone biopsy and culture
B) CT scan with IV contrast
C) Gadolinium-enhanced MRI
D) Tagged white blood cell scan
E) Triple phase bone scan

A

The correct response is Option A.

The preoperative management of pressure sores is vital to successful surgical outcomes and healing. When a patient presents, one of the first assessments must be whether that patient has evidence of osteomyelitis. For patients presenting with chronic exposed wounds at Stage III or Stage IV, the risk of pelvic osteomyelitis is very high. This will require intravenous antibiotic treatment and bony debridement prior to coverage. To establish this diagnosis, especially in a patient with an increased ESR, a bone biopsy is needed. This will help guide initiation and maintenance of treatment.

While a positive bone scan may indicate the presence of osteomyelitis, this test carries a high rate of false positives in patients with open wounds. Thus, the next line of workup for osteomyelitis would be a bone biopsy, with the tissue being sent for cultures and sensitivities. This should be done in such a way that some of the deeper pelvic bone is sampled, and not just the superficially exposed bone. This will allow for both diagnosis and a guide for directed antibiotic therapy.

In cases where bone biopsy is not available, a gadolinium-enhanced MRI or tagged white blood cell scan can be used to assess for the characteristic inflammation associated with osteomyelitis, and make a diagnosis indicating the need for antibiotic treatment. A CT scan with IV contrast is a last-line test used for this purpose, as it is less sensitive at showing localized inflammation, and is more helpful in assessing depth of invasion and defining exposed structures.

Thus, in this case, given the chronic nature of this open wound, and the fact that it is ready for closure based on clinical examination, a bone biopsy would be most helpful as the first step in ensuring there is no osteomyelitis prior to closure.

2018

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2
Q

An 84-year-old man comes to the office accompanied by his son-in-law for evaluation of an ulcer of the ischium. Physical examination of the patient shows not only a Stage IV ulcer of the right ischium, but also multiple bruises of the extremities including circumferential upper extremity ecchymoses. The son-in-law claims the patient sustained a fall, but the patient is silent and avoids eye contact when questioned. Because of the unusual physical findings and questionable history, elder abuse is suspected. Which of the following is the most appropriate response in this situation?

A) Proceed with excision and flap reconstruction of the ulcer since there is no definite proof of elder abuse
B) Pull the son-in-law aside and ask him in private about the suspected elder abuse
C) Referral to a wound care center
D) Report the suspected elder abuse to adult protective services
E) Report the suspicion of elder abuse only with the patient’s permission

A

The correct response is Option D.

Although elder abuse may be relatively rare in consultation, plastic surgeons must be aware that it is treated similarly to child abuse. The healthcare provider has a responsibility to report the suspected offense even if the patient denies the abuse if the physician has any reason to suspect that the elder abuse may be occurring. Elderly patients may be just as vulnerable as children to abuse and are often overlooked because of the fact that they frequently are competent adults. Similar to children, geriatric patients may be reluctant to report the abuse for fear of repercussions such as withholding of care. Breaching patient confidentiality rights is acceptable if the interests of the vulnerable patient are best served by reporting the incident in good faith and can be made without fear of liability to the provider. In these cases, delays in reporting may result in additional harm to the elderly person.

2018

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3
Q

A 45-year-old paraplegic man with a history of type 1 diabetes mellitus comes to the physician because of a stage 3 trochanteric pressure sore. The wound has been adequately debrided, and myocutaneous flap reconstruction is planned. Albumin concentration is 3.8 mg/dL, and hemoglobin A1c concentration is 6.3%. Diet includes protein intake of 2.5 g/kg daily. Which of the following factors is most likely to be associated with failure of the reconstruction?

A) Albumin concentration
B) Hemoglobin A1c
C) Patient age
D) Pressure sore location
E) Protein intake

A

The correct response is Option B.

Preoperative optimization is essential in patients undergoing pressure sore reconstruction. This includes adequate nutrition (albumin greater than 3.5 g/dL, 1.5 to 3.0 g/kg/day of protein intake, 25 to 35 cal/kg of nonprotein calories daily), eradication of infection, treatment of spasms/contractures, smoking cessation, urinary/stool diversion in select circumstances, and an appropriate postoperative plan of care including pressure off-loading. A multivariate analysis of risk factors for failure of pressure sore flap reconstruction included hemoglobin A1c greater than 6%, younger age, albumin concentration less than 3.5 g/dL, and ischial location. In this patient, the primary risk factor for failure of reconstruction would be a high hemoglobin A1c.

2017

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4
Q

A 22-year-old man who is a wheelchair-bound paraplegic is evaluated because of a recurrent pressure sore. The patient has had previous surgeries to repair a left trochanteric pressure sore and a large midline sacral pressure sore. A photograph is shown. The most appropriate treatment is debridement followed by coverage with which of the following?

A) Adjacent skin advancement
B) Gluteal fasciocutaneous flap
C) Posterior thigh musculocutaneous flap
D) Split-thickness skin graft
E) Tensor fascia lata flap

A

The correct response is Option C.

In this patient, a posterior thigh flap consisting of the biceps femoris, semitendinosus, and semimembranosus muscles and overlying skin is the most appropriate treatment option. Advantages of this flap include a reliable vascular supply (first perforating branch of profunda femoris artery), a generous amount of skin, fat, and muscle to obliterate the dead space after ulcer excision, and the ability to re-advance the flap in the event of ulcer recurrence. Additionally, a posterior thigh flap preserves other donor sites such as the medial thigh, lateral thigh, and gluteal muscles for secondary problems or the inevitable pressure sore in another location. The chief disadvantage of the posterior thigh flap is its upward mobility, as maximal movement is 10 to 12 cm. For extensive ischial defects, a second flap or another flap option may be necessary. Generally, this flap is limited to non-ambulatory patients due to the harvest of multiple knee flexors. Transfer of the biceps femoris alone has been described for small defects in ambulatory patients. The posterior thigh flap is a Mathes/Nahai Type II muscle, with a primary dominant pedicle (first perforating branch of the profunda femoris artery) with smaller segmental distal pedicles. These segmental secondary pedicles can typically be divided with little effect on flap survival. It is recommended that the origin and insertion of the muscles be divided to maximize flap mobility and minimize tension at the inset site. These flaps can be designed as a V-Y configuration or designed in a rotational configuration as shown in the perioperative photograph.

The temptation to perform a primary closure should be resisted, as pressure sores by definition indicate a soft tissue deficiency. Simply pulling tissues together over a bony prominence will very likely fail because of wound tension and dehiscence. In this patient, this was already attempted previously with a predictable outcome. Skin grafts have very limited success in this location because of a lack of bulk and resistance to pressure and shearing forces. The gluteal fasciocutaneous flap is based on the inferior gluteal artery and is a good option in the ambulatory patient with an ischial pressure sore. In this case, however, the pedicle is not available owing to the previous gluteal V-Y flap used to repair the sacral pressure sore. In cases when a gluteal fasciocutaneous flap has been utilized previously, the posterior thigh musculature may still be used in the face of a recurrent ischial pressure sore; however, a skin graft would be required.

The tensor fascia lata (TFL) flap is the first-line choice for trochanteric pressure sores and has already been used in this patient. The TFL has been described for ischial pressure sores, but only after more reliable flaps have been exhausted. Because the distal 6 to 8 cm of the TFL are unreliable, flap delay or pre-transfer expansion are recommended prior to transfer for an ischial reconstruction.

2017

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5
Q

A 40-year-old man with T3 paraplegia undergoes operative debridement of a stage III ischial decubitus ulcer. In the recovery room, the nurse reports that the patient is saying he has severe headache and nausea. Temperature is 37.0°C (99.0°F), blood pressure is 180/90 mmHg, and heart rate is 50 bpm. He is flushed and diaphoretic. Which of the following is the most appropriate initial management of this patient’s condition?

A) Administer dantrolene 2.5 mg/kg intravenously
B) Administer nitroglycerin lingual spray
C) Insert a Foley catheter
D) Perform carotid massage
E) Place patient in Trendelenburg position

A

The correct response is Option C.

This patient has autonomic dysreflexia (AD). During an episode of AD, the patient sustains an uncontrolled sympathetic response to a stimulus (precipitant). It usually occurs in patients whose level of paralysis is above T6. AD occurs in 50 to 70% of patients with lesions above T6. Fatal complications may ensue in affected patients.

Common symptoms of AD include headache, hypertension, bradycardia, and flushing, blotching, or sweating above the level of the lesion.

The most common precipitants of AD are urologic (principally bladder distention), gastrointestinal (rectal distention), and musculoskeletal (fractures, dislocations, and heterotopic calcification). Other less common precipitants include skin ulcerations and infections as well as pregnancy and labor.

Primary treatments of AD include removing any stimulus. Remove tight clothing and be sure that a full bladder or rectum is not serving as a precipitant. Sublingual nifedipine may be used secondarily as an oral hypotensive agent. Nitrates are not part of the initial management of AD. A fluid bolus would have no role in the treatment of AD or hypertensive crisis. Dantrolene is used in the management of malignant hyperthermia, not AD. Administration of dextrose in 50% water intravenously is used to manage symptomatic hypoglycemia.

Carotid massage causes vago stimulation and is contraindicated in this patient.

Trendelenburg is usually used for hypotension, not hypertension.

2017

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6
Q

A 46-year-old man is evaluated for a large grade IV left ischial pressure ulcer. Medical history includes a 6-month history of traumatic T12 paraplegia. Excision of the pressure ulcer and reconstruction with a left inferior gluteal thigh flap are planned. During induction of anesthesia, the patient has the onset of cardiac arrhythmia with peaked T waves and tachycardia. Pulse oximetry is 100% with normal end-tidal CO2. Temperature is 37.0°C (98.6°F). It is discovered that the patient was given succinylcholine for rapid-sequence intubation by the anesthesia resident. Which of the following is the most appropriate initial management of the patient’s condition?

A) Intravenous adenosine
B) Intravenous amiodarone
C) Intravenous calcium chloride
D) Intravenous dantrolene
E) Synchronized cardioversion

A

The correct response is Option C.

Perioperative complications arising from intravenous paralytics and inhalational anesthetics may have devastating outcomes, including death. Rapid and accurate diagnosis is essential for efficient treatment and maximizing successful outcomes. The paraplegic patient presented in this clinical scenario has developed acute hyperkalemia from the use of succinylcholine. Hyperkalemia after succinylcholine administration may result in paraplegics or any patients with upper or lower motor neuron injury, severe burns, crush injuries, or conditions causing rhabdomyolysis. This phenomenon results from the upregulation of nicotinic acetylcholine receptors in denervated or traumatized muscle.

Initial treatment of acute hyperkalemia causing cardiac compromise involves antagonizing the effects of potassium on cardiac conduction and shifting potassium from the extracellular space back into intracellular fluid. Calcium directly antagonizes the hyperkalemia-induced depolarization of resting membrane potential by increasing the threshold potential to stabilize the membrane. Sodium bicarbonate and glucose combined with insulin will promote cellular uptake of potassium. Acidosis enhances the release of potassium from the cell and can be reversed with sodium bicarbonate. In addition, alkalization of plasma decreases levels of ionized calcium permitting the more liberal use of calcium in the treatment of acute hyperkalemia.

Intravenous dantrolene is appropriate for the initial management of malignant hyperthermia (MH). MH may also arise from the use of succinylcholine or inhalational anesthetics. It is caused by a hereditary abnormality that interferes with calcium regulation within skeletal muscle. Once triggered, an uncontrolled hypermetabolism in the muscle occurs secondary to the buildup of calcium in the skeletal muscle. The earliest sign of malignant hyperthermia is a rapid and unexplained increase in end-tidal CO2 that progresses to the presence of fever. This patient is afebrile and has a normal end-tidal CO2. However, if the patient presentation did indeed suggest MH, intravenous calcium chloride would be contraindicated secondary to the already increased levels of calcium present.

Synchronous cardioversion and intravenous adenosine and amiodarone are modalities to consider in the ACLS algorithm for treatment of unstable and stable tachycardia of unknown etiology. They are not first-line medications in the treatment of the hyperkalemia that is causing this patient’s symptoms.

2017

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7
Q

An otherwise healthy 55-year-old man with paraplegia is evaluated because of a recurrent ischial pressure ulcer. History includes previous coverage of the ulcer with a posterior thigh rotation-advancement flap. After appropriate optimization of both patient and wound, which of the following is the most appropriate surgical intervention for reclosure of the wound?

A) Gracilis musculocutaneous flap
B) Inferior gluteal flap
C) Re-rotation of posterior thigh flap
D) Tensor fascia lata flap
E) V-Y hamstring flap

A

The correct response is Option C.

The most appropriate surgical treatment option would be to re-rotate the posterior thigh flap.

One of the main principles in surgical flap closure of pressure ulcers (PUs) is to utilize large rotation flaps so that they may be re-rotated in the case of recurrences. Although it is debatable whether to re-flap a patient who has a PU recurrence, some clinical situations require a redo flap closure. In those circumstances, instead of using a new flap or donor site, re-elevation of the original flap and re-advancing it is usually the first-line flap option. The posterior thigh flap is a fasciocutaneous flap based on the descending branch of the inferior gluteal artery (if elevated as a purely V-Y flap, or if raised as a superiorly based “tongue” flap). However, if elevated as a rotation-advancement flap, it also has blood flow from medial or lateral thigh skin perforators depending on where the flap incisions are made on the posterior thigh.

In all forms of the flap, the entire posterior thigh skin and fascia is elevated off the hamstring muscles (semitendinosus, semimembranosus, biceps femoris), thus severing all the musculocutaneous perforators from those muscles to the overlying skin and fascia. Therefore, the V-Y hamstring flap (a musculocutaneous flap) is not available after a posterior thigh flap has been raised. Though the inferior gluteal artery flap, gracilis, and possibly the tensor fascia lata flaps may be used, they are not the most appropriate surgical option when a re-rotation thigh flap is still available.

2016

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8
Q

A 45-year-old man is hospitalized in the intensive care unit for 3 weeks after sustaining blunt force trauma to the head during an assault and develops a pressure ulcer over the right ischium. Six weeks later, the wound has not healed despite multiple bedside debridements and daily wound care. The patient is ambulatory. Physical examination shows an 8 × 4 × 4-cm stage III pressure ulcer at the right inferior gluteal fold with an indurated bursa. After nutritional optimization, which of the following surgical techniques is most appropriate for closure after excising the bursa?

A) Gracilis musculocutaneous rotation flap
B) Negative pressure wound therapy then primary closure
C) Posterior thigh fasciocutaneous rotation flap
D) Superiorly based gluteal musculocutaneous rotation flap
E) Tensor fasciae latae island rotation flap

A

The correct response is Option C.

The best reconstructive option for an ambulatory patient with a chronic ischial pressure sore is to spare muscle and use a fasciocutaneous flap. Fasciocutaneous flaps offer an axial blood supply with durable coverage and minimal potential for a functional deformity. The flaps closely reconstruct the normal anatomical arrangement over bony prominences. Disadvantages include limited bulk to fill large defects.

Musculocutaneous flaps offer excellent blood supply and bulky tissue and can be re-rotated like fasciocutaneous flaps. However, in an ambulatory patient, they may cause functional impairment.

The tensor fasciae latae flap is occasionally used to close the ischial ulcer. Unfortunately, the distal aspect of the flap that is used to reach the ischial region is usually too thin to offer adequate padding to be effective. Therefore, this is not the most appropriate option.

Primary closure is associated with an increased rate of wound recurrence. A large dead space is usually present due to the absence of tissue, and the induration of adjacent areas makes them difficult to mobilize for a tension-free closure.

2016

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9
Q

A 66-year-old man with paraplegia is evaluated because of a 6-month history of Grade IV pressure ulcer. Medical history includes multiple debridements with appropriate off-loading and good wound care. The patient shows no clinical improvement. Chronic osteomyelitis is suspected. Which of the following is the most appropriate next step in diagnosis?

A) Bone biopsy
B) CT scan
C) Dual energy x-ray absorptiometry (DEXA) scan
D) MRI
E) Triphasic technetium scan

A

The correct response is Option A.

The accurate diagnosis of chronic osteomyelitis in long-standing wounds can be extremely difficult. The gold standard to diagnose chronic osteomyelitis is bone biopsy. Bone biopsy can provide histopathologic as well as microbiologic data that are sensitive and specific for chronic osteomyelitis.

Triphasic technetium-99 bone scan or scintigraphy is a nuclear study that serves as a functional test to assess bone metabolism. MRI uses a magnetic field and radio waves to reconstruct anatomical structures of interest. CT scan can reveal small areas of osteolysis, small foci of gas, or foreign bodies. Triphasic bone scan, MRI, and CT scan have all been used to evaluate for osteomyelitis clinically. However, these studies lack specificity and can be misleading in the presence of a chronic soft-tissue injury or previous bony injury from prior debridements.

A dual energy x-ray absorptiometry (DEXA) scan is a low-exposure x-ray study measuring bone density in order to assess for osteoporosis. It has no role in evaluating osteomyelitis.

2016

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10
Q

A 50-year-old man with paraplegia and diabetes mellitus is evaluated because of an ischial stage 4 pressure ulcer. Optimizing the patient’s nutrition and diabetic control is attempted, and aggressive resection of the ulcer and underlying bone with a locoregional flap closure is planned. Which of the following characteristics places this patient at increased risk for late recurrence of the ulcer?

A) Age greater than 45 years
B) Defect size greater than 20 cm2
C) Hemoglobin A1c of less than 6%
D) Location of ulcer
E) Osteomyelitis confirmed by bone biopsy

A

The correct response is Option D.

The risk factor in this patient associated with the greatest risk of late recurrence is ischial ulcer location.

The treatment of pressure ulcers remains a difficult problem for medical practitioners and plastic surgeons. In a recent study, risk factors were identified as predictors of flap failure after resection and reconstruction with a flap. Factors associated with dehiscence include age less than 45 years, history of previous same-site surgery failure, albumin concentration of less than 3.5 mg/dL, and poor diabetic control (hemoglobin A1c of more than 6%). Factors associated with recurrence include ischial wound location, previous same-site surgery failure, and poor diabetic control. Osteomyelitis confirmed by bone biopsy and size of defect were not associated with dehiscence or recurrence. Patients with multiple risk factors showed a dramatic trend toward dehiscence and flap failure.

Other studies corroborate the finding that ischial ulcer location is difficult for achieving coverage. This is most likely secondary to the high pressure over the ischial tuberosities in the seated position. Pressure maps have shown that, when seated, the pressure exceeds 80 to 100 mmHg compared with supine sacral pressures of 60 mmHg.

2015

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11
Q

A 47-year-old man with complete T12 paraplegia presents with a 5 × 5 × 4-cm stage IV sacral pressure ulcer. Physical examination shows the wound is clean with granulation tissue. Coverage with a local tissue flap is planned. In designing the flap, careful consideration must be made regarding which of the following?

A) Avoiding incisions near the anus to minimize bacterial contamination
B) Confining scar to a cosmetically acceptable location
C) Designing incisions allowing for future re-advancement
D) Localizing individual perforators
E) Preserving sensory innervation

A

The correct response is Option C.

A systematic review of the literature was performed by Sameem et al., to determine the relative efficacy of musculocutaneous versus fasciocutaneous versus perforator flaps in the treatment of pressure ulcers. In their analysis, they concluded that all flaps had a significant recurrence and complication rate; however, there was no difference between the types of flaps used. Their paper did not specifically address the issue of how patients’ conditions were subsequently managed when they did develop a recurrence. This is important, because a key surgical strategy is to consider the need for subsequent surgical procedures; in fact, perhaps more critical than the composition of the flap and the nature of its blood supply is the design of the flap and where the incisions are planned. A fundamental principle in surgical management of pressure ulcers is being able to provide healthy vascularized tissue into the wound bed and to completely obliterate dead space. Furthermore, the flap should be designed such that if a recurrence develops, the patient continues to have surgical options available, such as re-advancement or re-rotation of the prior flap(s).

Preservation of sensory innervation is important for patients who still have sensation in this area. However, in patients who are completely paraplegic, there is a lack of adequate sensory innervation and a lack of the ability to ambulate, which is what ultimately leads to the development of pressure ulcers.

Confining the scar to a cosmetically acceptable location is not a major priority in managing pressure ulcers. The cosmetic appearance of scars in this area is relatively unimportant in light of the presence of an open wound.

Localizing individual perforators is not necessary when large rotation or advancement flaps are designed. In those situations, a broad blood supply is maintained, and multiple perforators are typically kept intact and do not require individual localization or dissection. However, it is important when a single perforator flap is being designed. Perforator flaps when used as pedicle flaps may be more prone to venous congestion and slightly higher complication rates due to the delicate dissection and isolation of the sole blood supply, which in turn is more prone to mechanical twisting and kinking. Perforator flaps ideally preserve the muscular function of the donor site, which may not be important in a patient who is paraplegic.

2014

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12
Q

A 21-year-old ambulatory man with spina bifida at the level of S2 is scheduled to undergo closure of a stage IV ischial decubitus ulcer. Rotational flap closure is planned. Which of the following flaps is most appropriate considering wound closure and ambulation?

A) Gluteal thigh
B) Gluteus muscle
C) Hamstring
D) Reverse latissimus dorsi
E) Vastus lateralis

A

The correct response is Option A.

This patient, who has S2 paraplegia, has complete muscle function in the upper extremities, thoracic musculature, hips, and knees. Thus, detachment and relocation of hamstring muscles, the primary flexors of the knee, would greatly decrease this patient’s ability to ambulate. Although the vastus lateralis is a significant knee extender, and the use of this muscle would weaken the function of the quadriceps, other quadriceps muscles (vastus intermedius, vastus medialis, and rectus femoris) can sufficiently compensate for its loss.

Reverse latissimus dorsi can be useful for lower back and sacral coverage, but it does not have sufficient reach to cover the ischium. Tensor fascia lata assists in femoral flexion and abduction, but it is a minor muscle and has little functional impact. Gluteal thigh flaps are based on the descending gluteal artery and are typically raised as fasciocutaneous flaps. Thus, it would have little effect on ambulation or lower extremity motion.

2014

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13
Q

A 55-year-old man with an ulcer of the left ischium (stage 4) undergoes debridement, ostectomy, and transfer of a gluteal myocutaneous flap for closure of the wound. Which of the following risk factors is associated with the highest rate of recurrence?

A) Incontinence
B) Obesity
C) Paraplegia
D) Patient age
E) Vitamin deficiency

A

The correct response is Option C.

In a study out of Johns Hopkins, pressure ulcer patients who underwent reconstruction had a recurrence rate of 82% if they were paraplegic compared with 0% in non-paraplegic patients. Other risk factors for recurrence after repair include factors that predispose patients to prolonged pressure ischemia and/or reduced capacity for tissue repair. These include age greater than 70 years, immobility, poor nutrition, low BMI, anemia, diabetes, end-stage renal disease, cerebrovascular disease, hip fracture within 3 months, and prior pressure ulcer surgery. Although malnutrition is associated with pressure ulcers, micronutrient deficiencies such as vitamin C or zinc are not associated with formation or recurrence. A subsequent Cochrane Database Study showed that nutritional and vitamin supplementation is not associated with improved healing. There is no evidence to show that incontinence is associated with pressure ulcer formation or recurrence.

2019

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14
Q

A 48-year-old man with a 5-month history of traumatic paraplegia presents with a large grade IV right ischial pressure ulcer. The patient undergoes operative excision of the pressure ulcer and coverage with an inferior gluteal rotation flap. On induction of anesthesia, the patient has onset of cardiac arrhythmia with peaked T-waves, ventricular tachycardia, and hypotension. Pulse oximetry is 100% with normal end-tidal CO2. Temperature is 37.0ºC (98.6ºF). It is discovered that the patient was given succinylcholine for rapid sequence intubation. Which of the following laboratory abnormalities is most likely associated with this patient’s condition?

A) Hyperkalemia
B) Hypernatremia
C) Hypocalcemia
D) Hypoglycemia
E) Hypomagnesemia

A

The correct response is Option A.

Perioperative complications arising from intravenous paralytics and inhalational anesthetics may have devastating outcomes including death. Rapid and accurate diagnosis is essential for efficient treatment and maximizing successful outcomes. The paraplegic patient presented in this clinical vignette has developed acute hyperkalemia from the use of succinylcholine. Hyperkalemia after succinylcholine administration may result in paraplegics or any patients with upper or lower motor neuron injury, severe burns, crush injuries, or conditions causing rhabdomyolysis. This phenomenon results from the upregulation of nicotinic acetylcholine receptors in denervated or traumatized muscle.

Initial treatment of acute hyperkalemia causing cardiac compromise involves antagonizing the effects of potassium on cardiac conduction and shifting potassium from the extracellular space back into intracellular fluid. Calcium directly antagonizes the hyperkalemia-induced depolarization of resting membrane potential by increasing the threshold potential to stabilize the membrane. Sodium bicarbonate and glucose combined with insulin will promote cellular uptake of potassium. Acidosis enhances the release of potassium from the cell and can be reversed with sodium bicarbonate. In addition, alkalization of plasma decreases levels of ionized calcium permitting the more liberal use of calcium in the treatment of acute hyperkalemia.

While hypomagnesemia, hypoglycemia, hypernatremia, and hypocalcemia can all result in electrocardiography changes including tachycardia, prolonged QT interval, shortened PR interval, and ST depression, these electrolyte abnormalities are not the most likely to be associated with the clinical scenario.

2020

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15
Q

A 65-year-old man with a spinal cord injury and a chronic ischial pressure sore undergoes preoperative optimization with pressure offloading and nutritional supplementation. Medical history includes type 2 diabetes mellitus and chronic ischialosteomyelitis. The patient undergoes thorough debridement of the ulcer and myocutaneous flap reconstruction with appropriate intravenous antibiotic therapy. Four months after surgery, he presents to the clinic with a new wound in the same region as the previous reconstruction. Which of the following factors most likely led to the recurrence of the ischial pressure wound?

A) Hemoglobin A1c greater than 6%
B) Osteomyelitis
C) Patient age
D) Prealbumin less than 20 mg/dL

A

The correct response is Option A.

The presence of poor glycemic control, as indicated by a Hemoglobin A1c greater than 6%, is a predictor of recurrence of pressure ulcers. Age less than 45 years old at the time of surgery is a predictor of recurrence. Older age at the time of surgery appears to be protective against recurrence. The presence of osteomyelitis at the time of surgery does not appear to contribute to disease recurrence. A low prealbumin (less than 20 mg/dL) does not appear to contribute to recurrence when evaluated on multivariate models. Poor glycemic control contributes to disease recurrence as well as early return to the operating room for wound dehiscence.

2021

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16
Q

A 65-year-old man with a spinal cord injury presents with a right-sided sacral pressure ulcer wound that has been present for 12 months. He has no history of smoking or diabetes. Osteomyelitis has been controlled with oral antibiotics and his nutrition has been optimized. Physical examination shows a 6 × 5 × 4-cm wound overlying the sacrum. Which of the following is the most appropriate reconstructive choice for coverage of the wound?

A) Biceps femoris V-Y musculocutaneous advancement flap
B) Gluteal V-Y musculocutaneous advancement flap
C) Pedicled lumbosacral perforator flap
D) Pedicled tensor fascia lata flap

A

The correct response is Option B.

The most appropriate method of reconstruction of a deep sacral pressure wound is a gluteal-based advancement or rotation flap. In general, gluteal-based flaps are preferred for this area for reconstruction. Unilateral or bilateral flaps may be required, and the V-Y flap has the added benefit of being re-advanced for recurrent wounds or wound dehiscence. The pedicled tensor fascia lata flap will not reach a sacral wound. This flap is best used for deep trochanteric pressure ulcers. The biceps femoris V-Y musculocutaneous advancement flap is the mainstay of treatment for a deep ischial pressure ulcer. This is a posterior thigh flap that will not reach the sacral region as a pedicled flap. The pedicled lumbosacral perforator flap is small and is not suitable for deep sacral pressure ulcers. It may be useful for small wounds or superficial wounds, and is based on lumbar perforators.

2021

17
Q

A 52-year-old man with paraplegia presents with a stage IV right trochanteric pressure ulcer. Examination shows appropriate nutrition by history, laboratory values, and weight stability. He doesn’t smoke, has a pressure mattress at home, and has demonstrated compliance with pressure off-loading. At the time of pressure sore excision, which of the following reconstructive options is most appropriate for this patient?

A) Gluteus V-Y musculocutaneous advancement flap
B) Gracilis musculocutaneous flap
C) Posterior thigh musculocutaneous flap
D) Profunda artery perforator fasciocutaneous flap
E) Tensor fascia lata musculocutaneous flap

A

The correct response is Option E.

The correct flap option for this patient is the tensor fascia lata (TFL) musculocutaneous flap which can be advanced in either a V-Y fashion or as a retropositioned flap if the defect is on the posterior aspect of the trochanter. The pedicle to the TFL flap is the ascending branch of the lateral femoral circumflex artery, and the nerve supply to the skin paddle is through the lateral cutaneous sensory nerve of the thigh. The motor branch to the TFL muscle is a branch of the superior gluteal nerve. This musculocutaneous flap can be re-advanced if there is pressure sore recurrence. In the series referenced, 77% of patients reconstructed with this flap for trochanteric pressure sores healed uneventfully, while two-thirds of the remaining patients healed completely with local wound care. The gracilis and profunda artery perforator flaps have an arc of rotation that makes them more suited to ischial wounds and vaginal reconstructive indications. Gluteal advancement flaps are indicated for sacral pressure sore reconstruction, and posterior thigh flaps could reach the trochanteric surgical site but could not be re-advanced.

2022

18
Q

A 20-year-old ambulatory man with a history of prolonged hospitalization presents with an evolving sacral wound. The patient has adequate nutrition, and the wound is covered with a foam dressing. Which of the following is an independent risk factor for the development of a pressure ulcer in this patient?

A) Dry wound environment
B) Intact sensorium
C) Male sex
D) Serum prealbumin 20 mg/dL
E) Young age

A

The correct response is Option C.

Pressure sores develop from unrelieved pressure over a bony prominence. There are nearly 2.5 million pressure ulcers treated each year in the United States. They represent an 11-billion–dollar, labor-intensive task for our health care system. Prevention is key. Medical and socioeconomic conditions affect outcomes and these factors cannot always be controlled. However, mechanical prophylaxis, good nutrition, and prevention of underlying infection form the cornerstones of management. Independent risk factors for pressure sores include advanced age, male sex, altered sensorium, moisture, immobility, malnutrition, and friction/shear injury.

Nutritional status can be measured by the concentration of serum prealbumin. It is now preferred over albumin because of its shorter half-life and ability to show relative changes of the nutritional state. Prealbumin, also named transthyretin, is a transport protein for thyroid hormone and is synthesized by the liver and partly catabolized by the kidneys. Normal concentrations are 16 to 35 mg/

2022

19
Q

A 25-year-old ambulatory man is evaluated because of a recurrent sacral wound. One year ago, the patient had a prolonged hospitalization from coronavirus disease 2019 (COVID-19). During his hospitalization, he developed a sacral pressure ulcer that was treated using bone debridement and bilateral gluteal fasciocutaneous flaps that healed uneventfully. On examination today, the wound probes to bone, and healthy granulation tissue is visible. Which of the following is the most likely cause of this patient’s wound recurrence?

A) Malignancy
B) Malnutrition
C) Ongoing pressure
D) Osteomyelitis
E) Poor flap vascularity

A

The correct response is Option D.

Pressure ulcers, as their name implies, result from excess unaddressed pressure at sites of bony prominence. Pressure ulcers are a common problem with an acute care facility prevalence of nearly 15% in 1999. This clinical entity alone has a cost burden estimated between 11 and 26.8 billion dollars in the United States. Despite being common, healing a pressure ulcer is a difficult endeavor, requiring optimization of many factors. Wound recurrence is the most important outcome measure, with a widely reported range from 15 to 100%. Paraplegic patients have generally higher recurrence rates (up to 82% at 18 months) due to the lack of sensory awareness of ongoing pressure and greater difficulty in mobility.

Osteomyelitis is a common issue complicating ulcer care both in terms of local wound care and reconstructive surgical success. MRI is the diagnostic imaging modality of choice, with bone biopsy and culture serving as the gold standard for diagnosis. Proper control of
osteomyelitis through bony debridement and culture-driven antibiotics is paramount in successful treatment. This is the most likely cause of recurrence in this clinical scenario given the patient’s ambulatory status, excellent nutrition and health, low incidence of malignancy overall in this setting, and delayed occurrence.

Ongoing pressure is another common reason for wound recurrence after reconstruction, but it is less likely in this clinical scenario given the initial use of a pressure offloading mattress, ambulatory status, and lack of prior ulcer.

Malnutrition is another important cause of ongoing wound-healing difficulty, yet it is also unlikely in this scenario. The patient has a normal albumin concentration, satisfactory protein intake, and normal BMI, all consistent with a lack of protein malnutrition.

Malignancy can occur in areas of chronic inflammation, including chronic wounds. Termed a “Marjolin ulcer,” malignant transformation of a chronic injury site has been rarely reported.
These tumors are typically squamous cell carcinoma and aggressive, and they have a poor prognosis. They are most often associated with prior burn sites but have been reported in regions of chronic osteomyelitis.

Vascularity of the flaps chosen for reconstruction are an important concern. Poor vascularity will lead to compromised healing in the acute postoperative period. Recurrence that occurs many months after healing is not typically the result of a poorly vascularized flap.

2023

20
Q

A 70-year-old woman who is obese and has type 2 diabetes is evaluated because of a very painful violaceous plaque on the abdomen that has developed into a black eschar. The eschar is located at the site where the patient injects insulin. History also includes end-stage renal disease. Examination of a specimen obtained on biopsy at the border of the lesion shows calcification of small- and medium-sized vessels, microvascular thromboses, extravascular soft-tissue calcification, and panniculitis. Administration of which of the following is the most appropriate management for this condition?

A) Calcium carbonate
B) Corticosteroids
C) Iron infusion
D) Sodium thiosulfate
E) Warfarin

A

The correct response is Option D.

This patient has calciphylaxis. This condition causes extremely painful ischemic skin lesions due to calcification of small- and medium-sized vessels and microvascular thromboses. The
majority of patients have end-stage renal disease, although it can develop in patients with normal kidney function. Female sex and obesity are other risk factors. The diagnosis is based on clinical features in uremic patients. Pain out of proportion to physical findings is a prominent feature of the disease and may precede cutaneous lesions. Violaceous plaques, nodules, or skin erosions may progress to ulcers or eschars. Clinical diagnosis may not be straightforward in nonuremic patients and frequently requires a skin biopsy. Histologic features of calciphylaxis include intimal hyperplasia, calcification of small- and medium sized vessels, vascular thrombosis, extravascular soft-tissue calcification, panniculitis, epidermal necrosis, ulceration, and dermal necrosis. Laboratory tests may disclose hypercalcemia, hypo- or hyperphosphatemia, or increased parathyroid hormone concentrations, although these are frequently normal.

Debridement of nonviable tissue and pain control are the mainstay of treatment. Sodium thiosulfate has been shown to result in improvement or resolution of calciphylaxis in patients with renal failure, according to a recent meta-analysis. Sodium thiosulfate has chelating and vasodilatory properties. Thiosulfate is administered intravenously in the last 30 to 60 minutes of hemodialysis. It is not effective for nonuremic calciphylaxis. Using calcium-based phosphate binders, such as calcium carbonate, for management of hyperphosphatemia should be avoided since they cause a positive calcium load, which increases tissue calcification. Corticosteroids, due to their effect on mineral metabolism, have been identified as a risk factor for calciphylaxis progression. Vitamin K, through its actions on matrix proteins, is an inhibitor of calcification in vessel walls. Warfarin is a vitamin K antagonist and should therefore be stopped and replaced with a non-vitamin K oral anticoagulant. Iron therapy is thought to be a risk factor for calciphylaxis. Iron deposits have been found in areas of microvascular calcification in biopsy specimens taken from patients with calciphylaxis.

2023

21
Q

An otherwise healthy 45-year-old man with paraplegia is evaluated because of a clean, slow-healing ischial pressure ulcer. Closure of the ulcer with a proximally based posterior thigh fasciocutaneous transposition flap is planned. The axial blood flow to this flap is supplied by a branch of which of the following arteries?

A) Inferior gluteal
B) Lateral circumflex femoral
C) Profunda femoris
D) Superficial femoral
E) Superior gluteal

A

The correct response is Option A.

The axial blood flow to the posterior thigh fasciocutaneous flap is provided by the descending branch of the inferior gluteal artery.

This vessel runs axially along the posterior thigh, along a course from the midpoint between the ischial tuberosity and the greater trochanter proximally, and the popliteal fossa distally. The vessel runs alongside the posterior cutaneous nerve of the thigh. The posterior thigh skin also has contributions from perforators from the profunda system, through the underlying thigh musculature, which is the main blood flow of the hamstring muscle/musculocutaneous flaps. However, in a true proximally based posterior thigh fasciocutaneous flap, those perforators are transected when the flap is raised.

2023