primary biliary and co

Question 1

Cholestasis

Answer 1

Inflammation of the bile duct caused by the build up of hepatocytes

Question 2

What are the causes of Cholestasis?

Answer 2

• Drug use
• Viral hepatitis/alcoholic hepatitis
• Liver failure

Question 3

Primary biliary cholangitis

Answer 3

• Autoimmune disease which occurs primarily in women.
• Acts upon auto-mitochondrial proteins.
• Environmental trigger plays on genetic susceptibility.

Question 4

Main investigation for primary biliary cholangitis?

Answer 4

Increased serum amylase

Question 5

How does primary biliary cholangitis develop?

Answer 5

1-Chronic granulomatous inflammation
2-Loss of intra-hepatic bile ducts
3-Cirrhosis

Question 6

Primary sclerosis cholangitis

Answer 6

-Chronic inflammation of the bile ducts

Question 7

Investigations for primary sclerosing cholangitis?

Answer 7

• pANCA

- MRCP

Question 8

What conditions are associated with Primary scelrosing cholangitis

Answer 8

• IBD

- cholangiocarcinoma

Question 9

Treatment for PSC?

Answer 9

Biliary stents

Liver transplant

Question 10

Common diseases of the gallbladder?

Answer 10

Cholelithiasis
Cholesterosis (cholesterol in lining of gallbladder wall
GB polyps

Question 11

Benign biliary tract disease- congenital?

Answer 11

Congenital:

• Biliary atresia: flow of bile from liver to gallbladder is inhibited
• Cholechondral cysts: abnormal dilation of bile ducts which leads to the retention of bile

Question 12

Benign biliary tract disease stricture?

Answer 12

• Iatrogenic
• Gallstone related
• Inflammatory (can lead to PSC, HIV, Pancreatitis )