Ulcerative colitis Flashcards
1
Q
Definition
A
inflammatory bowel disease which is characterised by continuous inflammation of the rectum
2
Q
Histology
A
- No granulomas
- Crypt accesses
- Submucosal inflammation
- Depletion of goblet cells
3
Q
Causes (primary/secondary)
A
primary:
-autoimmune disease: T-cell depletion
Secondary:
- stress
- diet
4
Q
Risk factors
A
- Women
- hereditary
- caucasian
5
Q
Symptoms
A
- Lower left quadrant abdominal pain
- Diarrohea: blood in stool for 6 days
- Blood in stool
- weight loss
6
Q
Treatment
A
- steroids
- immunosuppressants
- biologics
- surgery
7
Q
What can Investigations reveal
A
Imaging can reveal the presence of ulcers and psudopolyps
8
Q
Hereditary risk
A
HLA gene
9
Q
Severe UC- SIGNS
A
6 or more bloody stools a day and
- fever
- tachycardia
- Raised CRP or ESR
- Anaemia
- low albumin
- leucocytosis or thrombocytosis
10
Q
what are leucocytosis and thrombocytosis
A
leuco: increased WBC
Thrombo: increased platelets
