Primary Structure Flashcards

(14 cards)

1
Q

What is the primary structure of a protein?

A

the peptide bond formation between amino acids.

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2
Q

Why is the primary structure difunctional and what is the significance of this?

A

It has a amino group one end and a carboxyl group on the other end which allows precise positioning of R groups and precise arrangements for specific and precise interactions

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3
Q

What type of bond is a peptide bond?

A

covalent pseudo double bond because of its resonance

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4
Q

What is an oligopeptide?

A

A short aa chain of 2-20 amino acids

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5
Q

How many amino acids typically constitute a protein?

A

50-2000 amino acids

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6
Q

What terminus is the amino group on?

A

N-terminus

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7
Q

what terminus is the carboxyl group on?

A

C-terminal

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8
Q

True or False. Rotation is permitted around single bonds in a polypeptide chain

A

True.

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9
Q

What angles do single bonds rotate around and what is the importance of this?

A

rotation around phi (⏀) and psi (⍦) angles is what allows the protein to fold.

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10
Q

True of False. Rotation is freely permitted at double bonds too.

A

False. Double bonds have limited rotation between trans orientation and cis orientation.

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11
Q

What is the cis orientation?

A

Where both alpha carbons are on the same side of the petite bond.

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12
Q

What is the trans orientation?

A

Where alpha carbons are on opposite sides of peptide bond.

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13
Q

True or False. Rotation is permitted around peptide bonds.

A

False. There is no rotation permitted.

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14
Q

What is the significance of disulphide crosslinks?

A

Allows increased diversity in creating different structures and confers satiability to proteins in harsh environments like extracellular proteins.

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