Primary Structure Flashcards
(14 cards)
What is the primary structure of a protein?
the peptide bond formation between amino acids.
Why is the primary structure difunctional and what is the significance of this?
It has a amino group one end and a carboxyl group on the other end which allows precise positioning of R groups and precise arrangements for specific and precise interactions
What type of bond is a peptide bond?
covalent pseudo double bond because of its resonance
What is an oligopeptide?
A short aa chain of 2-20 amino acids
How many amino acids typically constitute a protein?
50-2000 amino acids
What terminus is the amino group on?
N-terminus
what terminus is the carboxyl group on?
C-terminal
True or False. Rotation is permitted around single bonds in a polypeptide chain
True.
What angles do single bonds rotate around and what is the importance of this?
rotation around phi (⏀) and psi (⍦) angles is what allows the protein to fold.
True of False. Rotation is freely permitted at double bonds too.
False. Double bonds have limited rotation between trans orientation and cis orientation.
What is the cis orientation?
Where both alpha carbons are on the same side of the petite bond.
What is the trans orientation?
Where alpha carbons are on opposite sides of peptide bond.
True or False. Rotation is permitted around peptide bonds.
False. There is no rotation permitted.
What is the significance of disulphide crosslinks?
Allows increased diversity in creating different structures and confers satiability to proteins in harsh environments like extracellular proteins.
